Clinical endpoints in allergen immunotherapy: State of the art 2022

被引：3

作者：

van Wijk, R. Gerth ^{[1
,4
]}

Klimek, L. ^{[2
]}

Pfaar, O. ^{[3
]}

机构：

[1] Erasmus MC, Dept Internal Med, Sect Allergol & Clin Immunol, Rotterdam, Netherlands

[2] Zent Rhinol & Allergol, Wiesbaden, Germany

[3] Philipps Univ Marburg, Univ Klinikum Marburg, Sekt Rhinol & Allergie, Klin Hals Nasen Ohren Heilkunde Kopf & Hals Chirur, Marburg, Germany

[4] Erasmus MC, Abt Allergol klin Immunol, Abt Innere Med, Rotterdam, Netherlands

来源：

ALLERGOLOGIE | 2023年 / 46卷 / 03期

关键词：

allergen immunotherapy; endpoints; rhinitis; asthma; real-life studies; cost-effectiveness; ASTHMA; RHINOCONJUNCTIVITIS; EFFICACY; RHINITIS; ADULTS; TRIAL;

D O I：

10.5414/ALX02334E

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

110 years after the classical study by Noon, numerous studies have confirmed the efficacy of allergen immunotherapy. A variety of clinical endpoints have been used in these trials. This review gives an overview of clinical endpoints for randomized clini-cal trials on allergen immunotherapy (AIT) in rhinitis and asthma. In addition, real-life studies have been carried out with the same kind of endpoints. In general, AIT studies are characterized by a lack of standardized and validated outcome measures. For allergic rhinoconjunctivitis, digital tools have been developed to monitor patients. Such tools are particularly useful to obtain real-world evidence for AIT. Finally, well-accepted out-come measures are available for cost-effec-tiveness studies.

引用

页码：184 / 192

页数：9

共 50 条

[41] CLINICAL AND PHARMACOECONOMIC ASPECTS OF ALLERGEN IMMUNOTHERAPY IN THE SLOVAK REPUBLIC
Bielik, J.
Pruzinec, P.
Tor, P.
VALUE IN HEALTH, 2012, 15 (07) : A561 - A562
[42] Allergen specific immunotherapy of respiratory allergy: the clinical outcome
Nikolov, G.
Michova, A.
Hristova, M.
Kandova, Y.
Hristova, R.
Konstantinova, D.
Petrunov, B.
ADVANCES IN ALLERGY, ASTHMA AND IMMUNOLOGY: FROM BASIC SCIENCE TO CLINICAL MANAGEMENT (PROCEEDINGS OF THE III WORLD ASTHMA AND COPD FORUM AND WORLD FORUM OF PEDIATRICS), 2010, : 19 - 24
[43] Cellular immunotherapy: a clinical state-of-the-art of a new paradigm for cancer treatment
Rodriguez, Perez A.
Campillo-Davo, D.
Van Tendeloo, V. F. I.
Benitez-Ribas, D.
CLINICAL & TRANSLATIONAL ONCOLOGY, 2020, 22 (11): : 1923 - 1937
[44] Cellular immunotherapy: a clinical state-of-the-art of a new paradigm for cancer treatment
Á. Rodríguez Pérez
D. Campillo-Davo
V. F. I. Van Tendeloo
D. Benítez-Ribas
Clinical and Translational Oncology, 2020, 22 : 1923 - 1937
[45] ALLERGEN IMMUNOTHERAPY
EWAN, PW
CURRENT OPINION IN IMMUNOLOGY, 1989, 1 (04) : 672 - 678
[46] ALLERGEN IMMUNOTHERAPY
WHEELER, AW
CLINICAL AND EXPERIMENTAL ALLERGY, 1995, 25 (04): : 379 - 379
[47] Allergen Immunotherapy
Rael, Efren
PRIMARY CARE, 2016, 43 (03): : 487 - +
[48] Allergen immunotherapy
Rank, Matthew A.
Li, James T. C.
MAYO CLINIC PROCEEDINGS, 2007, 82 (09) : 1119 - 1123
[49] Allergen immunotherapy
Rogala, Barbara
ALERGIA ASTMA IMMUNOLOGIA, 2009, 14 (03): : 187 - 189
[50] Allergen immunotherapy
Crisafulli G.
Caminiti L.
Chiera F.
Ramistella V.
Arasi S.
Pajno G.B.
Italian Journal of Pediatrics, 40 (Suppl 1) : 1 - 2

← 1 2 3 4 5 →