Clinical endpoints in allergen immunotherapy: State of the art 2022

被引：3

作者：

van Wijk, R. Gerth ^{[1
,4
]}

Klimek, L. ^{[2
]}

Pfaar, O. ^{[3
]}

机构：

[1] Erasmus MC, Dept Internal Med, Sect Allergol & Clin Immunol, Rotterdam, Netherlands

[2] Zent Rhinol & Allergol, Wiesbaden, Germany

[3] Philipps Univ Marburg, Univ Klinikum Marburg, Sekt Rhinol & Allergie, Klin Hals Nasen Ohren Heilkunde Kopf & Hals Chirur, Marburg, Germany

[4] Erasmus MC, Abt Allergol klin Immunol, Abt Innere Med, Rotterdam, Netherlands

来源：

ALLERGOLOGIE | 2023年 / 46卷 / 03期

关键词：

allergen immunotherapy; endpoints; rhinitis; asthma; real-life studies; cost-effectiveness; ASTHMA; RHINOCONJUNCTIVITIS; EFFICACY; RHINITIS; ADULTS; TRIAL;

D O I：

10.5414/ALX02334E

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

110 years after the classical study by Noon, numerous studies have confirmed the efficacy of allergen immunotherapy. A variety of clinical endpoints have been used in these trials. This review gives an overview of clinical endpoints for randomized clini-cal trials on allergen immunotherapy (AIT) in rhinitis and asthma. In addition, real-life studies have been carried out with the same kind of endpoints. In general, AIT studies are characterized by a lack of standardized and validated outcome measures. For allergic rhinoconjunctivitis, digital tools have been developed to monitor patients. Such tools are particularly useful to obtain real-world evidence for AIT. Finally, well-accepted out-come measures are available for cost-effec-tiveness studies.

引用

页码：184 / 192

页数：9

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