Ru(II)-Catalyzed C-H Alkenylation of Benzimidates with Unactivated Olefins: A Route to ortho-Alkenylated Benzonitriles

被引：11
|
作者：
Shambhavi, Chikkabagilu Nagaraju [1 ]
Jeganmohan, Masilamani [1 ]
机构：
[1] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 02期
关键词：
OXIDATIVE CYCLIZATION; DIRECTING GROUP; BOND; ALKENES; ACTIVATION; ALKYNES; ARENES; FUNCTIONALIZATION; 1H-INDAZOLES; AROMATICS;
D O I：
10.1021/acs.orglett.2c04036
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Ru(II)-catalyzed C-H alkenylation of benzimidates with unac-tivated alkenes providing ortho-alkenylated benzonitriles in good to excellent yields in a highly regio-and stereoselective manner is described. In the reaction, an imidate group converted into a nitrile under the reaction conditions. The alkenylation reaction was compatible with various substituted benzimidates as well as functionalized unactivated olefins, including ibuprofen-, neproxen-, coumarin-, and cholesterol-substituted alkenes. A feasible reaction mechanism was proposed to account for the present alkenylation reaction.
引用
收藏
页码：358 / 363
页数：6
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