Ru(II)-Catalyzed C-H Alkenylation of Benzimidates with Unactivated Olefins: A Route to ortho-Alkenylated Benzonitriles

被引：11

作者：

Shambhavi, Chikkabagilu Nagaraju ^{[1
]}

Jeganmohan, Masilamani ^{[1
]}

机构：

[1] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 02期

关键词：

OXIDATIVE CYCLIZATION; DIRECTING GROUP; BOND; ALKENES; ACTIVATION; ALKYNES; ARENES; FUNCTIONALIZATION; 1H-INDAZOLES; AROMATICS;

D O I：

10.1021/acs.orglett.2c04036

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Ru(II)-catalyzed C-H alkenylation of benzimidates with unac-tivated alkenes providing ortho-alkenylated benzonitriles in good to excellent yields in a highly regio-and stereoselective manner is described. In the reaction, an imidate group converted into a nitrile under the reaction conditions. The alkenylation reaction was compatible with various substituted benzimidates as well as functionalized unactivated olefins, including ibuprofen-, neproxen-, coumarin-, and cholesterol-substituted alkenes. A feasible reaction mechanism was proposed to account for the present alkenylation reaction.

引用

页码：358 / 363

页数：6

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