Fenfluramine Treatment Is Associated With Improvement in Everyday Executive Function in Adults With Lennox-Gastaut Syndrome: Post-Hoc Analysis of Dose Effects From a Phase 3 Trial Rationale

被引：5

作者：

Bishop, Kim ^{[1
]}

Isquith, Peter ^{[1
,2
]}

Knupp, Kelly ^{[3
]}

Sullivan, Joseph ^{[4
]}

Nabbout, Rima ^{[5
]}

Gil-Nagel, Antonio ^{[6
]}

Scheffer, Ingrid ^{[7
,8
,9
]}

Auvin, Stephane ^{[10
]}

Cross, J. Helen ^{[11
]}

Guerrini, Renzo ^{[12
]}

Roth, Robert ^{[1
,13
]}

Gioia, Gerard ^{[1
,14
]}

Lothe, Amelie ^{[15
]}

Polega, Shikha ^{[16
]}

机构：

[1] Global Pharma Consultancy LLC, Muncy, PA USA

[2] Harvard Med Sch, Boston Childrens Hosp, Boston, MA USA

[3] Childrens Hosp Colorado, Aurora, CO USA

[4] Univ Calif San Francisco, Benioff Childrens Hosp, San Francisco, CA USA

[5] Univ Paris Cite, Hop Univ Necker Enfants Malad, APHP, Reference Ctr Rare Epilepsies,Inst Imagine,EPICAR, Paris, France

[6] Hosp Ruber Int, Madrid, Spain

[7] Univ Melbourne, Austin Hosp, Heidelberg, Vic, Australia

[8] Royal Childrens Hosp, Florey Inst, Parkville, Vic, Australia

[9] Murdoch Childrens Res Inst, Murdoch, WA, Australia

[10] Univ Paris, Robert Debre Univ Hosp, APHP, Inst Univ France IUF, Paris, France

[11] UCL NIHR BRC Great Ormond St Inst Child Hlth, London, England

[12] Univ Florence, Anna Meyer Childrens Hosp, Florence, Italy

[13] Dartmouth Hitchcock Med Ctr, Lebanon, NH USA

[14] Childrens Natl Hlth Syst, Washington, DC USA

[15] Zogenix Int, Maidenhead, England

[16] Zogenix Inc, Emeryville, CA USA

来源：

NEUROLOGY | 2023年 / 100卷 / 17期

关键词：

D O I：

10.1212/WNL.0000000000202479

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

P11-1.001

引用

页数：6

共 25 条

[1] RUFINAMIDE AS ADJUNCTIVE TREATMENT FOR ADULTS WITH LENNOX-GASTAUT SYNDROME: SUBGROUP ANALYSIS FROM A PHASE III TRIAL
Striano, P.
McMurray, R.
EPILEPSIA, 2015, 56 : 211 - 211
[2] Efficacy of Rufinamide as Adjunctive Treatment for Adults With Lennox-Gastaut Syndrome: Subgroup Analysis From a Phase III Trial
Striano, Pasquale
McMurray, Rob
NEUROLOGY, 2016, 86
[3] Efficacy of Rufinamide as Adjunctive Treatment for Adults With Lennox-Gastaut Syndrome: Subgroup Analysis From a Phase III Trial
Striano, Pasquale
McMurray, Rob
NEUROLOGY, 2016, 86
[4] Impact of Fenfluramine on Drop Seizure Frequency in Adults or Dose-Capped Patients With Lennox-Gastaut Syndrome: Comparative Analysis of Clinical Trial Data
Knupp, Kelly G.
Scheffer, Ingrid E.
Ceulemans, Berten
Sullivan, Joseph
Nickels, Katherine C.
Lagae, Lieven
Guerrini, Renzo
Zuberi, Sameer M.
Nabbout, Rima
Riney, Kate
Polega, Shikha
Lothe, Amelie
Davis, Ronald
Gil-Nagel, Antonio
NEUROLOGY, 2023, 100 (17)
[5] Impact of Fenfluramine on drop seizure frequency in adults or dose- capped patients with Lennox-Gastaut Syndrome: comparative analysis of clinical trial data
Scheffer, I. E.
Ceulemans, B.
Sullivan, J.
Nickels, K. C.
Lagae, L.
Guerrini, R.
Zuberi, S. M.
Nabbout, R.
Riney, K.
Polega, S.
Lothe, A.
Davis, R.
Gil-Nagel, A.
EPILEPSIA, 2023, 64 : 8 - 8
[6] Early and Sustained Treatment Effect of Adjunctive Perampanel in Patients with Seizures Associated with Lennox-Gastaut Syndrome (LGS): A Post Hoc Analysis
Patten, Anna
Morita-Sherman, Marcia
Ngo, Stella
NEUROLOGY, 2023, 100 (17)
[7] Improvement in Function After Lasmiditan Treatment: Post-Hoc Analysis of Pooled Data From Phase 3 Studies
Smith, T. R.
Hake, A.
Nery, E.
Rathmann, S.
Matthews, B.
Dowsett, S.
Doty, E.
HEADACHE, 2020, 60 : 109 - 110
[8] Improvement in Function after Lasmiditan Treatment: Post Hoc Analysis of Data from Phase 3 Studies
Timothy Smith
John H. Krege
Suchitrita S. Rathmann
Sherie A. Dowsett
Ann Hake
Emel S. M. Nery
Brandy R. Matthews
Erin G. Doty
Neurology and Therapy, 2020, 9 : 459 - 471
[9] Improvement in Function after Lasmiditan Treatment: Post Hoc Analysis of Data from Phase 3 Studies
Smith, Timothy
Krege, John H.
Rathmann, Suchitrita S.
Dowsett, Sherie A.
Hake, Ann
Nery, Emel S. M.
Matthews, Brandy R.
Doty, Erin G.
NEUROLOGY AND THERAPY, 2020, 9 (02) : 459 - 471
[10] Fenfluramine (Fintepla®) Treatment Improves Everyday Executive Functioning in Preschool Children with Dravet Syndrome: Analysis From 2 Pooled Phase 3 Clinical Trials
Bishop, Kim
Isquith, Peter K.
Gioia, Gerard A.
Knupp, Kelly G.
Scheffer, Ingrid E.
Sullivan, Joseph
Nabbout, Rima
Polega, Shikha
Plasch, Anna
Galer, Bradley S.
Shore, Svetlana
Gammaitoni, Arnold R.
NEUROTHERAPEUTICS, 2022, 19 (04) : 1426 - 1426

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