Impact of Fenfluramine on Drop Seizure Frequency in Adults or Dose-Capped Patients With Lennox-Gastaut Syndrome: Comparative Analysis of Clinical Trial Data

被引：0

作者：

Knupp, Kelly G. ^{[1
]}

Scheffer, Ingrid E. ^{[2
]}

Ceulemans, Berten ^{[3
]}

Sullivan, Joseph ^{[4
]}

Nickels, Katherine C. ^{[5
]}

Lagae, Lieven ^{[6
]}

Guerrini, Renzo ^{[7
,8
]}

Zuberi, Sameer M. ^{[9
]}

Nabbout, Rima ^{[10
]}

Riney, Kate ^{[11
,12
]}

Polega, Shikha ^{[13
]}

Lothe, Amelie ^{[14
]}

Davis, Ronald ^{[15
]}

Gil-Nagel, Antonio ^{[16
]}

机构：

[1] Univ Colorado, Childrens Hosp Colorado, Aurora, CO USA

[2] Univ Melbourne, Austin Hosp, Royal Childrens Hosp, Melbourne, Vic, Australia

[3] Univ Antwerp Hosp, Dept Paediat Neurol, Antwerp, Belgium

[4] Univ Calif San Francisco, Benioff Childrens Hosp, Weill Inst Neurosci, San Francisco, CA USA

[5] Mayo Clin, Dept Neurol, Rochester, MN USA

[6] Univ Leuven, Dept Paediat Neurol, Leuven, Belgium

[7] Univ Florence, Anna Meyer Childrens Hosp, Pediat Neurol & Neurogenet Unit, Florence, Italy

[8] IRCCS Fondazione Stella Maris, Pisa, Italy

[9] Royal Hosp Children Glasgow, Paediat Neurosci Res Grp, Glasgow, Lanark, Scotland

[10] Univ Paris Cite, APHP, Hosp Univ Necker Enfants,Inst Imagine, Reference Ctr Rare Epilepsies,Member EPICARE, Paris, France

[11] Queensland Childrens Hosp, Neurosci Unit, South Brisbane, Qld, Australia

[12] Univ Queensland, Sch Clin Med, St Lucia, Qld, Australia

[13] Zogenix Inc, Emeryville, CA USA

[14] Zogenix Int LTD, Maidenhead, Berks, England

[15] Neurol & Epilepsy Res Ctr, Orlando, FL USA

[16] Hosp Ruber Int, Madrid, Spain

来源：

NEUROLOGY | 2023年 / 100卷 / 17期

关键词：

D O I：

10.1212/WNL.0000000000202351

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

S44.002

引用

页数：7

共 37 条

[1] Impact of Fenfluramine on drop seizure frequency in adults or dose- capped patients with Lennox-Gastaut Syndrome: comparative analysis of clinical trial data
Scheffer, I. E.
Ceulemans, B.
Sullivan, J.
Nickels, K. C.
Lagae, L.
Guerrini, R.
Zuberi, S. M.
Nabbout, R.
Riney, K.
Polega, S.
Lothe, A.
Davis, R.
Gil-Nagel, A.
EPILEPSIA, 2023, 64 : 8 - 8
[2] The impact of seizure frequency on quality of life in patients with Lennox-Gastaut syndrome or Dravet syndrome
Auvin, Stephane
Damera, Vidya
Martin, Monique
Holland, Rowena
Simontacchi, Kelly
Saich, Andrew
EPILEPSY & BEHAVIOR, 2021, 123
[3] Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome A Randomized Clinical Trial
Knupp, Kelly G.
Scheffer, Ingrid E.
Ceulemans, Berten
Sullivan, Joseph E.
Nickels, Katherine C.
Lagae, Lieven
Guerrini, Renzo
Zuberi, Sameer M.
Nabbout, Rima
Riney, Kate
Shore, Svetlana
Agarwal, Anupam
Lock, Michael
Farfel, Gail M.
Galer, Bradley S.
Gammaitoni, Arnold R.
Davis, Ronald
Gil-Nagel, Antonio
JAMA NEUROLOGY, 2022, 79 (06) : 554 - 564
[4] Practical considerations for the use of fenfluramine to manage patients with Dravet syndrome or Lennox-Gastaut syndrome in clinical practice
Wirrell, Elaine C.
Lagae, Lieven
Scheffer, Ingrid E.
Cross, J. Helen
Specchio, Nicola
Strzelczyk, Adam
EPILEPSIA OPEN, 2024, 9 (05) : 1643 - 1657
[5] Fenfluramine provides clinically meaningful reduction in frequency of drop seizures in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study
Knupp, Kelly G.
Scheffer, Ingrid E.
Ceulemans, Berten
Sullivan, Joseph
Nickels, Katherine C.
Lagae, Lieven
Guerrini, Renzo
Zuberi, Sameer M.
Nabbout, Rima
Riney, Kate
Agarwal, Anupam
Lock, Michael
Dai, David
Farfel, Gail M.
Galer, Bradley S.
Gammaitoni, Arnold R.
Polega, Shikha
Davis, Ronald
Gil-Nagel, Antonio
EPILEPSIA, 2023, 64 (01) : 139 - 151
[6] Clobazam Is Efficacious for Drop Attacks in Patients with Lennox-Gastaut Syndrome across the Age Spectrum: Subgroup Analysis of the CONTAIN Trial
Mitchell, Wendy
Conry, Joan
Ng, Yu-tze
Drummond, Rebecca
Owen, Randall
NEUROLOGY, 2012, 78
[7] Effects of rufinamide on the frequency of different seizure types in patients with Lennox-Gastaut syndrome: A long-term study
Glauser, T.
Kluger, G.
Krauss, G.
Arroyo, S.
EPILEPSIA, 2007, 48 : 156 - 156
[8] Fenfluramine Treatment Is Associated With Improvement in Everyday Executive Function in Adults With Lennox-Gastaut Syndrome: Post-Hoc Analysis of Dose Effects From a Phase 3 Trial Rationale
Bishop, Kim
Isquith, Peter
Knupp, Kelly
Sullivan, Joseph
Nabbout, Rima
Gil-Nagel, Antonio
Scheffer, Ingrid
Auvin, Stephane
Cross, J. Helen
Guerrini, Renzo
Roth, Robert
Gioia, Gerard
Lothe, Amelie
Polega, Shikha
NEUROLOGY, 2023, 100 (17)
[9] RUFINAMIDE AS ADJUNCTIVE TREATMENT FOR ADULTS WITH LENNOX-GASTAUT SYNDROME: SUBGROUP ANALYSIS FROM A PHASE III TRIAL
Striano, P.
McMurray, R.
EPILEPSIA, 2015, 56 : 211 - 211
[10] Efficacy of Rufinamide as Adjunctive Treatment for Adults With Lennox-Gastaut Syndrome: Subgroup Analysis From a Phase III Trial
Striano, Pasquale
McMurray, Rob
NEUROLOGY, 2016, 86

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