Better together: Non-additive interactions between schizophrenia risk genes

被引：0
|
作者：
Deans, P. J. Michael [1 ,2 ]
Brennand, Kristen J. [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, Div Mol Psychiat, Dept Psychiat, New Haven, CT 06511 USA
[2] Yale Univ, Dept Genet, Div Mol Psychiat, Sch Med, New Haven, CT 06511 USA
来源：
CELL GENOMICS | 2023年 / 3卷 / 09期
关键词：
DISEASE;
D O I：
10.1016/j.xgen.2023.100403
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Zhang, Zhang, Forrest et al combine allele-specific open chromatin (ASoC) mapping and CRISPR-editing to evaluate the functional impact of schizophrenia risk variants on human neuronal gene expression, synaptic development, and function. In doing so, they uncover surprising non-additive effects between target genes regulated by the same risk variant.
引用
收藏
页数：3
相关论文
共 50 条
  • [41] A Note on the Connection between Non-Additive Entropy and h-Derivative
    Muthuvel, Kothandapani
    Sawangtong, Panumart
    Kaliraj, Kalimuthu
    FRACTAL AND FRACTIONAL, 2023, 7 (06)
  • [42] Non-additive effects between genotypes: Implications for competitive fitness assays
    Xiao, Changyi
    Duarri-Redondo, Sara
    Thorhoelludottir, Dagny A. V.
    Chen, Yiwen
    Schloetterer, Christian
    ECOLOGY AND EVOLUTION, 2023, 13 (11):
  • [43] A Note on the Connection between Non-Additive Entropy and h-Derivative
    Kang, Jin-Wen
    Shen, Ke-Ming
    Zhang, Ben-Wei
    ENTROPY, 2023, 25 (06)
  • [44] Lane formation in binary complex plasmas: Role of non-additive interactions and initial configurations
    Jiang, K.
    Du, C. -R.
    Suetterlin, K. R.
    Ivlev, A. V.
    Morfill, G. E.
    EPL, 2010, 92 (06)
  • [45] DECOMPOSITION TECHNIQUES FOR LARGE-SCALE SYSTEMS WITH NON-ADDITIVE INTERACTIONS - STABILITY AND STABILIZABILITY
    VIDYASAGAR, M
    IEEE TRANSACTIONS ON AUTOMATIC CONTROL, 1980, 25 (04) : 773 - 779
  • [46] The effect of non-additive genetic interactions on selection in multi-locus genetic models
    J Hallander
    P Waldmann
    Heredity, 2007, 98 : 349 - 359
  • [47] Non-additive and epistatic effects of HLA polymorphisms contributing to risk of adult glioma
    Zhang, Chenan
    de Smith, Adam J.
    Smirnov, Ivan V.
    Wiencke, John K.
    Wiemels, Joseph L.
    Witte, John S.
    Walsh, Kyle M.
    JOURNAL OF NEURO-ONCOLOGY, 2017, 135 (02) : 237 - 244
  • [48] Non-additive effects of two substituents in disubstituted benzenes in terms of indirect interorbital interactions
    Gineityte, V
    JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM, 2001, 546 : 107 - 117
  • [49] Non-Additive Increases in Sediment Stability Are Generated by Macroinvertebrate Species Interactions in Laboratory Streams
    Albertson, Lindsey K.
    Cardinale, Bradley J.
    Sklar, Leonard S.
    PLOS ONE, 2014, 9 (08):
  • [50] Comparison of the non-additive interactions of an organophosphorus pesticide mixture in adult and preweanling rats.
    Moser, V. C.
    NEUROTOXICOLOGY, 2006, 27 (05) : 899 - 899
12345