Better together: Non-additive interactions between schizophrenia risk genes

被引：0
|
作者：
Deans, P. J. Michael [1 ,2 ]
Brennand, Kristen J. [1 ,2 ]
机构：
[1] Yale Univ, Sch Med, Div Mol Psychiat, Dept Psychiat, New Haven, CT 06511 USA
[2] Yale Univ, Dept Genet, Div Mol Psychiat, Sch Med, New Haven, CT 06511 USA
来源：
CELL GENOMICS | 2023年 / 3卷 / 09期
关键词：
DISEASE;
D O I：
10.1016/j.xgen.2023.100403
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Zhang, Zhang, Forrest et al combine allele-specific open chromatin (ASoC) mapping and CRISPR-editing to evaluate the functional impact of schizophrenia risk variants on human neuronal gene expression, synaptic development, and function. In doing so, they uncover surprising non-additive effects between target genes regulated by the same risk variant.
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页数：3
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