FOXO3a functions as a transcriptional and co-transcriptional splicing regulator in vascular endothelial cell lines

被引：1
|
作者：
Abudureyimu, Shajidan [1 ]
He, Chunhui [2 ]
Xie, Wei [3 ]
Chen, Zhuo [4 ]
Airikenjiang, Halisha [1 ]
Abulaiti, Dilihumaer [1 ]
Cao, Yan [5 ]
Qiu, Haitang [1 ]
Gao, Ying [1 ]
机构：
[1] Xinjiang Med Univ, Dept Comprehens Internal Med, Affiliated Hosp 1, Urumqi 830011, Xinjiang, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, China Heart Failure Ctr, Natl Ctr Cardiovasc Dis,State Key Lab Cardiovasc D, Beijing 100010, Peoples R China
[3] Xinjiang Prod & Construct Corps Hosp, Dept Cardiol, Urumqi 830011, Xinjiang, Peoples R China
[4] Xinjiang Med Univ, Clin Med Coll 2, Urumqi 830011, Xinjiang, Peoples R China
[5] Xinjiang Med Univ, Dept Hepatobiliary & Pancreat Surg, Affiliated Canc Hosp, Urumqi 830000, Xinjiang, Peoples R China
来源：
GENE | 2024年 / 904卷
关键词：
Coronary heart disease; FOXO3a; Targeted regulation; Alternative splicing; CORONARY-ARTERY-DISEASE; EXPRESSION; APOPTOSIS; PATHOPHYSIOLOGY; INSULIN;
D O I：
10.1016/j.gene.2024.148221
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent studies have indicated a connection between Forkhead box O3a protein and coronary artery disease, yet the exact role of FOXO3a in the regulation of metabolic processes and apoptosis in vascular endothelial cells is still unknown. Therefore, we investigated the role of FOXO3a on target genes in a human vascular endothelial cell line. Through the utilization of high-throughput sequencing technology, we analyzed gene expression profiles and alternative splicing patterns in human vascular endothelial cells with FOXO3a over expression. This study identified 419 DEGs between FOXO3a-OE HUVEC model and control cells. KEGG analysis indicated that the upregulated genes were mainly enriched in inflammation-related signaling pathways, and the downregulated genes were enriched in lipid metabolism-related pathways.
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页数：9
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