FOXO3a functions as a transcriptional and co-transcriptional splicing regulator in vascular endothelial cell lines

被引：1
|
作者：
Abudureyimu, Shajidan [1 ]
He, Chunhui [2 ]
Xie, Wei [3 ]
Chen, Zhuo [4 ]
Airikenjiang, Halisha [1 ]
Abulaiti, Dilihumaer [1 ]
Cao, Yan [5 ]
Qiu, Haitang [1 ]
Gao, Ying [1 ]
机构：
[1] Xinjiang Med Univ, Dept Comprehens Internal Med, Affiliated Hosp 1, Urumqi 830011, Xinjiang, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, China Heart Failure Ctr, Natl Ctr Cardiovasc Dis,State Key Lab Cardiovasc D, Beijing 100010, Peoples R China
[3] Xinjiang Prod & Construct Corps Hosp, Dept Cardiol, Urumqi 830011, Xinjiang, Peoples R China
[4] Xinjiang Med Univ, Clin Med Coll 2, Urumqi 830011, Xinjiang, Peoples R China
[5] Xinjiang Med Univ, Dept Hepatobiliary & Pancreat Surg, Affiliated Canc Hosp, Urumqi 830000, Xinjiang, Peoples R China
来源：
GENE | 2024年 / 904卷
关键词：
Coronary heart disease; FOXO3a; Targeted regulation; Alternative splicing; CORONARY-ARTERY-DISEASE; EXPRESSION; APOPTOSIS; PATHOPHYSIOLOGY; INSULIN;
D O I：
10.1016/j.gene.2024.148221
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Recent studies have indicated a connection between Forkhead box O3a protein and coronary artery disease, yet the exact role of FOXO3a in the regulation of metabolic processes and apoptosis in vascular endothelial cells is still unknown. Therefore, we investigated the role of FOXO3a on target genes in a human vascular endothelial cell line. Through the utilization of high-throughput sequencing technology, we analyzed gene expression profiles and alternative splicing patterns in human vascular endothelial cells with FOXO3a over expression. This study identified 419 DEGs between FOXO3a-OE HUVEC model and control cells. KEGG analysis indicated that the upregulated genes were mainly enriched in inflammation-related signaling pathways, and the downregulated genes were enriched in lipid metabolism-related pathways.
引用
收藏
页数：9
相关论文
共 50 条
  • [21] Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis
    Barreyro, Fernando J.
    Kobayashi, Shogo
    Bronk, Steven F.
    Werneburg, Nathan W.
    Malhi, Harmeet
    Gores, Gregory J.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (37) : 27141 - 27154
  • [22] Transcriptional regulation of Bim by FOXO3A mediates hepatocytes lipoapoptosis
    Barreyro, Fernando
    Bronk, Steven F.
    Werneburg, Nathan W.
    Kobayashi, Shogo
    Malhi, Harmeet
    Gores, Gregory J.
    GASTROENTEROLOGY, 2007, 132 (04) : A736 - A736
  • [23] Coupling of co-transcriptional splicing and 3' end Pol II pausing during termination in Arabidopsis
    Zhou, Sixian
    Zhao, Fengli
    Zhu, Danling
    Zhang, Qiqi
    Dai, Ziwei
    Wu, Zhe
    GENOME BIOLOGY, 2023, 24 (01)
  • [24] Coupling of co-transcriptional splicing and 3’ end Pol II pausing during termination in Arabidopsis
    Sixian Zhou
    Fengli Zhao
    Danling Zhu
    Qiqi Zhang
    Ziwei Dai
    Zhe Wu
    Genome Biology, 24
  • [25] Does co-transcriptional regulation of alternative splicing mediate plant stress responses?
    Jabre, Ibtissam
    Reddy, Anireddy S. N.
    Kalyna, Maria
    Chaudhary, Saurabh
    Khokhar, Waqas
    Byrne, Lee J.
    Wilson, Cornelia M.
    Syed, Naeem H.
    NUCLEIC ACIDS RESEARCH, 2019, 47 (06) : 2716 - 2726
  • [26] The In Vivo Kinetics of RNA Polymerase II Elongation during Co-Transcriptional Splicing
    Brody, Yehuda
    Neufeld, Noa
    Bieberstein, Nicole
    Causse, Sebastien Z.
    Boehnlein, Eva-Maria
    Neugebauer, Karla M.
    Darzacq, Xavier
    Shav-Tal, Yaron
    PLOS BIOLOGY, 2011, 9 (01)
  • [27] Splicing in two yeasts is predominantly co-transcriptional and can already be detected close to the 3′ splice site
    Herzel, L.
    Oesterreich, F. Carrillo
    Neugebauer, K. M.
    FEBS JOURNAL, 2015, 282 : 212 - 212
  • [28] Soluble syntaxin 3 functions as a transcriptional regulator
    Giovannone, Adrian J.
    Winterstein, Christine
    Bhattaram, Pallavi
    Reales, Elena
    Low, Seng Hui
    Section, Julie E. Baggs
    Xu, Mimi
    Lalli, Matthew A.
    Paragraph, John B. Hogenesch
    Weimbs, Thomas
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 293 (15) : 5478 - 5491
  • [29] Co-transcriptional splicing efficiency is a gene-specific feature that can be regulated by TGFβ
    Sanchez-Escabias, Elena
    Guerrero-Martinez, Jose A.
    Reyes, Jose C.
    COMMUNICATIONS BIOLOGY, 2022, 5 (01)
  • [30] Co-transcriptional splicing efficiency is a gene-specific feature that can be regulated by TGFβ
    Elena Sánchez-Escabias
    José A. Guerrero-Martínez
    José C. Reyes
    Communications Biology, 5
12345