Ozanimod-Associated Iatrogenic Kaposi Sarcoma in a Patient With Ulcerative Colitis

被引：1
|
作者：
Sandlow, Sarah [1 ]
Rai, Puja [2 ]
Shum, Ann [2 ]
Chen, Hannah [3 ]
Arnold, Jeffrey [3 ]
Jangi, Sushrut [2 ]
机构：
[1] Tufts Univ, Medford, MA USA
[2] Tufts Med Ctr, Div Gastroenterol Hepatol, Boston, MA 02155 USA
[3] Tufts Med Ctr, Dept Pathol & Lab Med, Boston, MA USA
来源：
ACG CASE REPORTS JOURNAL | 2023年 / 10卷 / 02期
关键词：
INDUCTION;
D O I：
10.14309/crj.0000000000000929
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Ozanimod is an oral sphingosine-1-phosphate receptor modulator. Although it can be an effective drug for the induction and maintenance of remission in patients with moderately to severely active ulcerative colitis, there have been a few reported cases of various malignancies after exposure to this small molecule. We describe a unique case of biopsy-proven Kaposi sarcoma of the skin and colon in a patient with biologic-resistant ulcerative colitis after treatment with ozanimod for 2 months. Given the potential risk of malignancy associated with this agent, physicians should be aware of this rare adverse event.
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