Ozanimod-Associated Iatrogenic Kaposi Sarcoma in a Patient With Ulcerative Colitis

被引：1

作者：

Sandlow, Sarah ^{[1
]}

Rai, Puja ^{[2
]}

Shum, Ann ^{[2
]}

Chen, Hannah ^{[3
]}

Arnold, Jeffrey ^{[3
]}

Jangi, Sushrut ^{[2
]}

机构：

[1] Tufts Univ, Medford, MA USA

[2] Tufts Med Ctr, Div Gastroenterol Hepatol, Boston, MA 02155 USA

[3] Tufts Med Ctr, Dept Pathol & Lab Med, Boston, MA USA

来源：

ACG CASE REPORTS JOURNAL | 2023年 / 10卷 / 02期

关键词：

INDUCTION;

D O I：

10.14309/crj.0000000000000929

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Ozanimod is an oral sphingosine-1-phosphate receptor modulator. Although it can be an effective drug for the induction and maintenance of remission in patients with moderately to severely active ulcerative colitis, there have been a few reported cases of various malignancies after exposure to this small molecule. We describe a unique case of biopsy-proven Kaposi sarcoma of the skin and colon in a patient with biologic-resistant ulcerative colitis after treatment with ozanimod for 2 months. Given the potential risk of malignancy associated with this agent, physicians should be aware of this rare adverse event.

引用

页数：3

共 50 条

[31] SAFETY AND EFFICACY OF VEDOLIZUMAB IN A HIV POSITIVE PATIENT WITH KAPOSI'S SARCOMA AND SEVERE ULCERATIVE COLITIS: REPORT OF A CASE
Pagnini, C.
Di Paolo, M. C.
Torcolacci, F.
De Angelis, G.
Milano, M.
Trinca, D.
Di Sora, F.
Graziani, M. G.
DIGESTIVE AND LIVER DISEASE, 2020, 52 : S128 - S129
[32] Ozanimod as Induction and Maintenance Therapy for Ulcerative Colitis
Sandborn, William J.
Feagan, Brian G.
D'Haens, Geert
Wolf, Douglas C.
Jovanovic, Igor
Hanauer, Stephen B.
Ghosh, Subrata
Petersen, AnnKatrin
Hua, Steven Y.
Lee, Ji Hwan
Charles, Lorna
Chitkara, Denesh
Usiskin, Keith
Colombel, Jean-Frederic
Laine, Loren
Danese, Silvio
NEW ENGLAND JOURNAL OF MEDICINE, 2021, 385 (14): : 1280 - 1291
[33] POPULATION PHARMACOKINETICS AND PHARMACODYNAMICS OF OZANIMOD IN ULCERATIVE COLITIS
Tatosian, Daniel
Shen, Jun
Chen, Lu
Lavigne, Jean
Teuscher, Nathan
Harris, Sarah
Chitkara, Denesh
Tirucherai, Giridhar
Marta, Cecilia
GASTROENTEROLOGY, 2022, 162 (03) : S16 - S16
[34] Kaposi sarcoma associated with human immunodeficiency virus and iatrogenic Cushing syndrome
Kazmierczyk, K.
Schroeder, K.
August, S.
BRITISH JOURNAL OF DERMATOLOGY, 2012, 167 : 118 - 119
[35] KAPOSI SARCOMA IN AN IMMUNOSUPPRESSED PATIENT WITH PRESUMED CROHN'S DISEASE: IATROGENIC OR EPIDEMIC?
Claytor, Jennifer
Viramontes, Omar
Conner, Stephanie
Wen, Kwun Wah
Beck, Kendall
INFLAMMATORY BOWEL DISEASES, 2021, 27 : S1 - S1
[36] KAPOSI SARCOMA IN AN IMMUNOSUPPRESSED PATIENT WITH PRESUMED CROHN'S DISEASE: IATROGENIC OR EPIDEMIC?
Claytor, Jennifer
Viramontes, Omar
Conner, Stephanie
Wen, Kwun Wah
Beck, Kendall
GASTROENTEROLOGY, 2021, 160 (03) : S1 - S1
[37] Kaposi Sarcoma Following Liver Transplantation in a Patient With Ulcerative Pancolitis on Vedolizumab
Ramakrishnan, Pavithra
Hassan, Mohamed A.
Cartwright, David
Amin, Khalid
Aby, Elizabeth S.
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2023, 118 (10): : S2170 - S2170
[38] Human Herpesvirus 8-Associated Colonic Kaposi's Sarcoma in a HIV-Negative Drug-Induced Immunocompromised Patient With Ulcerative Colitis
Parikh, Jignesh
Hanna, Atef
Goodman, Susan
Moody, Laura
Makapugay, Jackie
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2014, 142
[39] Kaposi sarcoma-associated herpesvirus human herpesvirus type 8 and Epstein-Barr virus in iatrogenic Kaposi sarcoma
Henghold, WB
Purvis, SF
Schaffer, J
Leonard, DGB
Giam, CZ
Wood, GS
ARCHIVES OF DERMATOLOGY, 1997, 133 (01) : 109 - 111
[40] Judicious Use of Ozanimod for Ulcerative Colitis and Multiple Sclerosis
Jhon, Gabriela F.
Forster, Erin M.
ACG CASE REPORTS JOURNAL, 2024, 11 (04)

← 1 2 3 4 5 →