Suppressor-type TERT mutations associated with recurrence in ovarian clear cell carcinoma

被引：1
|
作者：
Kobayashi, Tatsuya [1 ,3 ]
Nishikimi, Kyoko [1 ,3 ]
Mitsuhashi, Akira [1 ,2 ]
Piao, Hongying [1 ]
Matsuoka, Ayumu [1 ]
Otsuka, Satoyo [1 ]
Tate, Shinichi [1 ]
Shozu, Makio [1 ]
Usui, Hirokazu [1 ]
机构：
[1] Chiba Univ, Grad Sch Med, Dept Reprod Med, Chiba, Japan
[2] Dokkyo Med Univ, Sch Med, Dept Obstet & Gynecol, Mibu, Tochigi, Japan
[3] Chiba Univ, Dept Reprod Med, Inohana 1-8-1, Chuo-ku, Chiba, Chiba 2608670, Japan
来源：
GENES CHROMOSOMES & CANCER | 2023年 / 62卷 / 08期
基金：
日本学术振兴会;
关键词：
enhancer-type" TERT promoter mutation; suppressor-type" TERT promoter mutation; ovarian cancer; ovarian clear cell carcinoma; recurrence; telomerase reverse transcriptase; telomere; REVERSE-TRANSCRIPTASE PROMOTER; TELOMERASE; ENDOMETRIAL; RESISTANCE; MECHANISMS;
D O I：
10.1002/gcc.23129
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Several cancers harbor "enhancer-type" mutations of the telomerase reverse transcriptase (TERT) promoter for immortalization. Here, we report that 8.6% (8/93) of ovarian clear cell carcinomas (OCCCs) possess the "suppressor-type" TERT promoter mutation. The recurrence rate of OCCCs with "suppressor-type" TERT promoter mutations was 62.5% (5/8) and was significantly higher than that of the "unaffected-type" with no mutation (20.8%, 15/72) or "enhancer-type" TERT promoter mutations (7.7%, 1/13). Our findings show that the acquired suppression of TERT is closely associated with OCCC development and recurrence, indicating the need for further research on telomerase suppression in cancers.
引用
收藏
页码：471 / 476
页数：6
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