Suppressor-type TERT mutations associated with recurrence in ovarian clear cell carcinoma

被引：1
|
作者：
Kobayashi, Tatsuya [1 ,3 ]
Nishikimi, Kyoko [1 ,3 ]
Mitsuhashi, Akira [1 ,2 ]
Piao, Hongying [1 ]
Matsuoka, Ayumu [1 ]
Otsuka, Satoyo [1 ]
Tate, Shinichi [1 ]
Shozu, Makio [1 ]
Usui, Hirokazu [1 ]
机构：
[1] Chiba Univ, Grad Sch Med, Dept Reprod Med, Chiba, Japan
[2] Dokkyo Med Univ, Sch Med, Dept Obstet & Gynecol, Mibu, Tochigi, Japan
[3] Chiba Univ, Dept Reprod Med, Inohana 1-8-1, Chuo-ku, Chiba, Chiba 2608670, Japan
来源：
GENES CHROMOSOMES & CANCER | 2023年 / 62卷 / 08期
基金：
日本学术振兴会;
关键词：
enhancer-type" TERT promoter mutation; suppressor-type" TERT promoter mutation; ovarian cancer; ovarian clear cell carcinoma; recurrence; telomerase reverse transcriptase; telomere; REVERSE-TRANSCRIPTASE PROMOTER; TELOMERASE; ENDOMETRIAL; RESISTANCE; MECHANISMS;
D O I：
10.1002/gcc.23129
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Several cancers harbor "enhancer-type" mutations of the telomerase reverse transcriptase (TERT) promoter for immortalization. Here, we report that 8.6% (8/93) of ovarian clear cell carcinomas (OCCCs) possess the "suppressor-type" TERT promoter mutation. The recurrence rate of OCCCs with "suppressor-type" TERT promoter mutations was 62.5% (5/8) and was significantly higher than that of the "unaffected-type" with no mutation (20.8%, 15/72) or "enhancer-type" TERT promoter mutations (7.7%, 1/13). Our findings show that the acquired suppression of TERT is closely associated with OCCC development and recurrence, indicating the need for further research on telomerase suppression in cancers.
引用
收藏
页码：471 / 476
页数：6
相关论文
共 50 条
  • [21] Frequent Activating Mutations of PIK3CA in Ovarian Clear Cell Carcinoma
    Kuo, Kuan-Ting
    Mao, Tsui-Lien
    Jones, Sian
    Veras, Emanuela
    Ayhan, Ayse
    Wang, Tian-Li
    Glas, Ruth
    Slamon, Dennis
    Velculescu, Victor E.
    Kuman, Robert J.
    Shih, Ie-Ming
    AMERICAN JOURNAL OF PATHOLOGY, 2009, 174 (05): : 1597 - 1601
  • [22] Predicting recurrence in clear cell Renal Cell Carcinoma
    Mukherjee, Gargi
    Bhanot, Gyan
    Raines, Kevin
    Sastry, Srikanth
    Doniach, Sebastian
    Biehl, Michael
    2016 IEEE CONGRESS ON EVOLUTIONARY COMPUTATION (CEC), 2016, : 656 - 661
  • [23] High frequency of neoantigens per mutation is a risk factor for recurrence in ovarian clear cell carcinoma
    Hasegawa, Kosei
    Matsushita, Hirokazu
    Oda, Katsutoshi
    Yamamoto, Shogo
    Nishijima, Akira
    Kurosaki, Akira
    Asada, Kayo
    Ikeda, Yuji
    Fujiwara, Keiichi
    Aburatani, Hiroyuki
    Kakimi, Kazuhiro
    CANCER SCIENCE, 2018, 109 : 128 - 128
  • [24] TERT promoter mutations are associated with poor prognosis in cutaneous squamous cell carcinoma
    Campos, Manuel Antonio
    Macedo, Sofia
    Fernandes, Margarida
    Pestana, Ana
    Pardal, Joana
    Batista, Rui
    Vinagre, Joao
    Sanches, Agostinho
    Baptista, Armando
    Lopes, Jose Manuel
    Soares, Paula
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2019, 80 (03) : 660 - +
  • [25] TYPE OF TREATMENT FACILITY IMPACTS SURVIVAL OF PATIENTS WITH OVARIAN CLEAR CELL CARCINOMA
    Nasioudis, D.
    Haggerty, A.
    Giuntoli, R., II
    Burger, R.
    Morgan, M.
    Ko, E.
    Latif, N.
    INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2018, 28 : 787 - 787
  • [26] Ovarian clear cell carcinoma associated with endometriosis: a case report with immunohistochemical study
    Murta, E. F. C.
    Nomelini, R. S.
    Ferreira, Ea.
    Lima, M. A.
    EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2007, 28 (05) : 403 - 405
  • [27] Identification of serum cytokine clusters associated with outcomes in ovarian clear cell carcinoma
    Akira Yabuno
    Hirokazu Matsushita
    Tetsutaro Hamano
    Tuan Zea Tan
    Daisuke Shintani
    Nao Fujieda
    David S. P. Tan
    Ruby Yun-Ju Huang
    Keiichi Fujiwara
    Kazuhiro Kakimi
    Kosei Hasegawa
    Scientific Reports, 10
  • [28] Molecular portraits of clear cell ovarian and endometrial carcinoma with comparison to clear cell renal cell carcinoma
    Ackroyd, Sarah A.
    Arguello, David
    Ramos, Pilar
    Mahdi, Haider
    ElNaggar, Adam
    Winer, Ira
    Holloway, Rob
    Krivak, Thomas
    Jones, Nathaniel
    Turner, Valerie Galvan
    Herzog, Thomas
    Chu, Christina
    Brown, Jubilee
    Mantia-Smaldone, Gina
    GYNECOLOGIC ONCOLOGY, 2023, 169 : 164 - 171
  • [29] Molecular portraits of clear cell ovarian and endometrial carcinoma with comparison to clear cell renal cell carcinoma
    Mantia-Smaldone, G. M.
    Arguello, D.
    Mahdi, H.
    ElNaggar, A. C.
    Winer, I.
    Holloway, R. W.
    Krivak, T. C.
    Jones, N. L.
    Galvan-Turner, V.
    Herzog, T. J.
    Chu, C.
    Brown, J.
    GYNECOLOGIC ONCOLOGY, 2019, 154 : 175 - 175
  • [30] Ovarian Clear Cell Carcinoma with Functioning Stroma and Associated Endometrial Intraepithelial Neoplasia
    Desimpel, Fabian
    Noel, Jean-Christophe
    Verset, Laurine
    Sirtaine, Nicolas
    Buxant, Frederic
    CASE REPORTS IN OBSTETRICS AND GYNECOLOGY, 2022, 2022
12345