Low-dose targeted alpha therapy induces strong anti-tumor effectiveness in combination with immune checkpoint inhibitors

被引：0
|
作者：
Rodman, Samuel [1 ]
Cagle, Brianna [1 ]
Liu, Dijie [2 ]
Schultz, Michael [3 ]
Li, Mengshi [2 ]
机构：
[1] Viewpoint Mol Targeting Inc, Coralville, IA USA
[2] Perspect Therapeut Inc, Seattle, WA USA
[3] Univ Iowa, Iowa City, IA 52242 USA
来源：
NUCLEAR MEDICINE AND BIOLOGY | 2023年 / 126卷
关键词：
FDA APPROVAL; METASTATIC MELANOMA; NIVOLUMAB;
D O I：
暂无
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
P-285
引用
收藏
页码：S261 / S262
页数：2
相关论文
共 50 条
  • [41] Local therapy with combination TLR agonists stimulates systemic anti-tumor immunity and sensitizes tumors to immune checkpoint blockade
    Rwandamuriye, Francois Xavier
    Wang, Tao
    Zhang, Hanfu
    Elaskalani, Omar
    Kuster, Jorren
    Ye, Xueting
    Vitali, Breana
    Schreurs, Juliet
    Morales, M. Lizeth Orozco
    Norret, Marck
    Evans, Cameron W.
    Zemek, Rachael M.
    Iyer, K. Swaminathan
    Lesterhuis, W. Joost
    Wylie, Ben
    ONCOIMMUNOLOGY, 2024, 13 (01):
  • [42] Enhancement of anti-tumor activity by low-dose combination of the recombinant urokinase kringle domain and celecoxib in a glioma model
    Kim, Chung Kwon
    Joe, Young Ae
    Lee, Suk-Keun
    Kim, Eun-Kyoung
    Eunju, O.
    Kim, Hyun-Kyung
    Oh, Bae Jun
    Hong, Sung Hee
    Hong, Yong-Kil
    CANCER LETTERS, 2010, 288 (02) : 251 - 260
  • [43] SYNERGISTIC PERITONEAL ANTI-TUMOR EFFECT OF ALLOCETRAOTS, A CELLULAR IMMUNE-THERAPY, IN COMBINATION WITH IMMUNE CHECKPOINT INHIBITORS/CHEMOTHERAPY, THROUGH IN-VIVO REPROGRAMMING OF MACROPHAGES AND DENDRITIC CELLS
    Mevorach, D.
    Shabat, Y.
    Regev, E.
    CYTOTHERAPY, 2023, 25 (06) : S239 - S239
  • [44] Improving anti-tumor efficacy of low-dose Vincristine in rhabdomyosarcoma via the combination therapy with FOXM1 inhibitor RCM1
    Donovan, Johnny
    Deng, Zicheng
    Bian, Fenghua
    Shukla, Samriddhi
    Gomez-Arroyo, Jose
    Shi, Donglu
    Kalinichenko, Vladimir V.
    Kalin, Tanya V.
    FRONTIERS IN ONCOLOGY, 2023, 13
  • [45] Impact of JAK inhibitors on anti-tumor immunity after RT combined with immune checkpoint inhibition
    Gissibl, Julia
    Timnik, Vincent R.
    Diederich, Sarah
    Felchle, Hannah
    Nefzger, Sophie M.
    Walther, Caroline N.
    Combs, Stephanie E.
    Fischer, Julius C.
    RADIOTHERAPY AND ONCOLOGY, 2024, 194 : S5188 - S5189
  • [46] Brachytherapy dose heterogeneity primes response to immune checkpoint blockade to generate anti-tumor immunity
    Jagodinsky, Justin C.
    Jin, Wonjong
    Vera, Jessica M.
    Sriramaneni, Raghava N.
    Clark, Paul A.
    Lan, Keng-Hsueh S.
    Chakravarty, Ishan
    Siegel, Noah
    Allawi, Raad H.
    Emma, Sarah E.
    Arthur, Ian S.
    Das, Rupak K.
    Ong, Irene M.
    Miller, Jessica R.
    Morris, Zachary S.
    CANCER RESEARCH, 2022, 82 (12)
  • [47] Efficacy of combination of immune checkpoint inhibitors, chemotherapy, and targeted therapy in advanced/refractory cancer.
    Salem, Philip A.
    Gensini, Lorenzo
    McCallum, William G. B.
    Hanna, John
    Wheeler, Thomas M.
    Stenoien, Randall A.
    Jabboury, Khaled W.
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (23_SUPPL) : 41 - 41
  • [48] Targeted delivery of a combination therapy consisting of combretastatin A4 and low-dose doxorubicin against tumor neovasculature
    Yang, Tingyuan
    Wang, Yiguang
    Li, Zaiquan
    Dai, Wenbing
    Yin, Jie
    Liang, Liang
    Ying, Xue
    Zhou, Shufeng
    Wang, Jiancheng
    Zhang, Xuan
    Zhang, Qiang
    NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2012, 8 (01) : 81 - 92
  • [49] TUMOR ASSOCIATED ANTIGEN VACCINE ENHANCES ANTI-TUMOR EFFECTS OF IMMUNE CHECKPOINT INHIBITORS AGAINST REFRACTORY CANCERS
    Ueda, Shohei
    Ushijima, Miho
    Irie, Atsushi
    Nishimura, Yasuharu
    Eto, Masatoshi
    JOURNAL OF UROLOGY, 2023, 209 : E732 - E732
  • [50] Carbon Therapy in Combination with Immune Checkpoint Inhibitors induces Antitumor defects in local and distal Tumors
    Helm, A.
    Simoniello, P.
    Tinganelli, W.
    Kurosawa, F.
    Fournier, C.
    Shimokawa, T.
    Durante, M.
    STRAHLENTHERAPIE UND ONKOLOGIE, 2020, 196 (SUPPL 1) : S28 - S28
12345