The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in (3-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in (3-cell physiology and plays a role in expansion of (3-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insu-lin release in human and rodent islets in vitro. Herein, we focus on the role of se-rotonin and melatonin in islet physiology and the pathophysiology of T2DM. This includes effects on hormone secretion, receptor expression, genetic variants influencing (3-cell function, melatonin treatment, and compounds that alter sero-tonin availability and signaling.
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Univ British Columbia, Life Sci Inst, Dept Cellular & Physiol Sci, Vancouver, BC, CanadaUniv British Columbia, Life Sci Inst, Dept Cellular & Physiol Sci, Vancouver, BC, Canada
Hall, Liam G.
Thyfault, John P.
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Univ Kansas, Med Ctr, Dept Cell Biol & Physiol, Kansas City, KS USA
Univ Kansas, Med Ctr, Dept Internal Med, Div Endocrinol & Metab, Kansas City, KS USA
Univ Kansas, KU Diabet Inst, Med Ctr, Kansas City, KS USAUniv British Columbia, Life Sci Inst, Dept Cellular & Physiol Sci, Vancouver, BC, Canada
Thyfault, John P.
Johnson, James D.
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Univ British Columbia, Life Sci Inst, Dept Cellular & Physiol Sci, Vancouver, BC, CanadaUniv British Columbia, Life Sci Inst, Dept Cellular & Physiol Sci, Vancouver, BC, Canada
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Univ British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, CanadaUniv British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, Canada
Park, Yoo Jin
Warnock, Garth L.
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Univ British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, CanadaUniv British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, Canada
Warnock, Garth L.
Ao, Ziliang
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Univ British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, CanadaUniv British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, Canada
Ao, Ziliang
Safikhan, Nooshin
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Univ British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, CanadaUniv British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, Canada
Safikhan, Nooshin
Meloche, Mark
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Univ British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, CanadaUniv British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, Canada
Meloche, Mark
Asadi, Ali
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Univ British Columbia, Fac Med, Dept Cellular & Physiol Sci, Vancouver, BC, CanadaUniv British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, Canada
Asadi, Ali
Kieffer, Timothy J.
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Univ British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, Canada
Univ British Columbia, Fac Med, Dept Cellular & Physiol Sci, Vancouver, BC, CanadaUniv British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, Canada
Kieffer, Timothy J.
Marzban, Lucy
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Univ British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, CanadaUniv British Columbia, Fac Med, Dept Surg, Rm 288,VGH Res Pavil,828 W 10th Ave, Vancouver, BC V5Z 1M9, Canada
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Capital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R China
Zhu, Bin
Zhang, Lei
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Capital Med Univ, Beijing Shijitan Hosp, Dept Pharm, Beijing 100038, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R China
Zhang, Lei
Zhang, Yue-Ying
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Beijing Hepingli Hosp, Dept Chinese Med, Beijing 100013, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R China
Zhang, Yue-Ying
Wang, Lei
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Beijing Univ Chinese Med, Affiliated Hosp 3, Dept Chinese Med, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R China
Wang, Lei
Li, Xin-Gang
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Capital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R China
Li, Xin-Gang
Liu, Teng
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Capital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R China
Liu, Teng
Fu, Yu-Ke
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Capital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R China
Fu, Yu-Ke
Zheng, Yan-Fei
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机构:
Beijing Univ Chinese Med, Affiliated Hosp 3, Dept Chinese Med, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R China
Zheng, Yan-Fei
Li, Ping
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China Japan Friendship Hosp, Dept Nephrol, Beijing 100029, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R China
Li, Ping
Zhao, Zhi-Gang
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Capital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R ChinaCapital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing 100050, Peoples R China