Monoamines' role in islet cell function and type 2 diabetes risk

被引:5
|
作者
Roberts, Fiona Louise [1 ]
Cataldo, Luis Rodrigo [1 ,2 ]
Fex, Malin [1 ]
机构
[1] Lund Univ, Diabet Ctr, Dept Clin Sci, Unit Mol Metab, SE-21428 Malmo, Sweden
[2] Univ Copenhagen, Novo Nord Fdn Ctr Basic Metab Res, Fac Hlth & Med Sci, DK-2200 Copenhagen, Denmark
基金
瑞典研究理事会;
关键词
PANCREATIC BETA-CELLS; SEROTONIN REUPTAKE INHIBITORS; STIMULATED INSULIN-SECRETION; FASTING PLASMA-GLUCOSE; SELECTIVE SEROTONIN; MELATONIN RECEPTORS; GLUCAGON-SECRETION; ENDOCRINE PANCREAS; GENE-EXPRESSION; MTNR1B;
D O I
10.1016/j.molmed.2023.08.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in (3-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in (3-cell physiology and plays a role in expansion of (3-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insu-lin release in human and rodent islets in vitro. Herein, we focus on the role of se-rotonin and melatonin in islet physiology and the pathophysiology of T2DM. This includes effects on hormone secretion, receptor expression, genetic variants influencing (3-cell function, melatonin treatment, and compounds that alter sero-tonin availability and signaling.
引用
收藏
页码:1045 / 1058
页数:14
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