Chromium-Catalyzed Defluorinative Reductive Coupling of Aldehydes with gem-Difluoroalkenes

被引：6

作者：

Liu, Yu-Tao ^{[1
]}

Fan, Yu-Hang ^{[1
]}

Mei, Yan ^{[1
]}

Li, Dong-Jie ^{[1
]}

Jiang, Yan ^{[1
]}

Yu, Wen-Hao ^{[1
]}

Pan, Fei ^{[1
]}

机构：

[1] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610068, Peoples R China

来源：

ORGANIC LETTERS | 2023年 / 25卷 / 03期

基金：

中国国家自然科学基金;

关键词：

ELECTROORGANIC CHEMISTRY; OLEFINIC KETONES; PHOTOREDOX;

D O I：

10.1021/acs.orglett.3c00016

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, a mild and convenient defluorinative reductive cross coupling of gem-difluoroalkenes with aliphatic aldehydes has been developed to afford diverse silyl-protected beta-fluorinated allylic alcohols. The reaction is operationally simple and shows good functional group tolerance with moderate to excellent yields. The utility of this method is demonstrated by converting the products into various bioactive fluorinated compounds, showing its potential applications in drug discovery and biochemistry.

引用

页码：549 / 554

页数：6

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