Synthesis of gem-difluoroalkenes via nickel-catalyzed allylic defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides

被引：25
|
作者：
Lu, Xiao-Yu [1 ,2 ]
Jiang, Run-Chuang [1 ]
Li, Jia-Mei [1 ]
Liu, Chuang-Chuang [1 ]
Wang, Qing-Qing [1 ]
Zhou, Hai-Pin [1 ]
机构：
[1] ChuZhou Univ, Sch Mat & Chem Engn, Chu Zhou 239000, Peoples R China
[2] Anhui Univ, Sch Chem & Chem Engn, Hefei 230601, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2020年 / 18卷 / 19期
基金：
安徽省自然科学基金;
关键词：
HECK-TYPE REACTION; C-F; DIAZO-COMPOUNDS; FLUORINE; DIFLUOROOLEFINATION; DIFLUOROCARBENE; PHARMACEUTICALS; ALKYNES;
D O I：
10.1039/d0ob00535e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A nickel-catalyzed defluorinative reductive cross-coupling of trifluoromethyl alkenes with epoxides has been developed. Various substituted trifluoromethyl alkenes and epoxides were found to be suitable reaction substrates. This reaction enabled C(sp(3))-C(sp(3)) bond construction through allylic defluorinative cross-coupling of trifluoromethyl alkenes under mild reaction conditions. This methodology was highly compatible with various sensitive functional groups, providing access to a diverse array of functionalized gem-difluoroalkene-containing alcohol compounds.
引用
收藏
页码：3674 / 3678
页数：5
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