Defluorinative Thiolation of gem-Difluoroalkenes by Convergent Paired Electrolysis

Herein, we have successfully developed a convergent pairedelectrolysisstrategy for the defluorinative thiolation process utilizing thiolsand gem-difluoroalkenes as precursors. This protocolexhibits remarkable tolerance toward a wide range of functional groups,as exemplified by the successful late-stage defluorothiolation ofcomplex molecules. Additionally, this strategy is amenable to gram-scalesynthesis, making use of both anodic oxidation and cathodic reductionprocesses in an efficient manner. Several control studies were conductedand suggested a convergent paired electrolysis mechanism.