Non-transferrin-bound iron takes the driver's seat

被引：5
|
作者：
Knutson, Mitchell D. [1 ]
机构：
[1] Univ Florida, Gainesville, FL 32611 USA
来源：
BLOOD | 2023年 / 141卷 / 03期
关键词：
D O I：
10.1182/blood.2022019049
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Charlebois et al(1) report that non-transferrin-bound iron (NTBI) is the primary driver of bone morphogenetic protein 6 (BMP6) expression in liver sinusoidal endothelial cells (LSECs) during iron overload. This finding is important because LSEC-derived BMP6 prompts the liver to produce hepcidin, the chief iron-regulatory hormone that regulates body iron balance.
引用
收藏
页码：214 / 216
页数：3
相关论文
共 50 条
  • [41] CHARACTERIZATION OF NON-TRANSFERRIN-BOUND IRON CLEARANCE BY RAT-LIVER
    WRIGHT, TL
    BRISSOT, P
    MA, WL
    WEISIGER, RA
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1986, 261 (23) : 909 - 914
  • [42] Pitfalls in assessing specificity and affinity of non-transferrin-bound iron uptake
    Brunner-Döpper, L
    Kriegerbeckova, K
    Kovar, J
    Goldenberg, H
    ANALYTICAL BIOCHEMISTRY, 1998, 261 (01) : 128 - 130
  • [43] Differential accumulation of non-transferrin-bound iron by cardiac myocytes and fibroblasts
    Liu, Y
    Parkes, JG
    Templeton, DA
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2003, 35 (05) : 505 - 514
  • [44] LC-ICP-MS CHARACTERIZATION OF NON-TRANSFERRIN-BOUND IRON
    Dziuba, Nathanial
    Hardy, Joanne
    Lindahl, Paul
    AMERICAN JOURNAL OF HEMATOLOGY, 2017, 92 (08) : E315 - E315
  • [45] Levels of non-transferrin-bound iron as an index of iron overload in patients with thalassaemia intermedia
    Taher, Ali
    Musallam, Khaled M.
    El Rassi, Fouad
    Duca, Lorena
    Inati, Adlette
    Koussa, Suzane
    Cappellini, Maria D.
    BRITISH JOURNAL OF HAEMATOLOGY, 2009, 146 (05) : 569 - 572
  • [46] Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera
    Evans, Robert W.
    Rafique, Roozina
    Zarea, Adel
    Rapisarda, Chiara
    Cammack, Richard
    Evans, Patricia J.
    Porter, John B.
    Hider, Robert C.
    JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY, 2008, 13 (01): : 57 - 74
  • [47] IRON OVERLOAD AND NON-TRANSFERRIN-BOUND IRON DURING BONE-MARROW TRANSPLANTATION
    DURKEN, M
    NOBEL, S
    NIELSEN, P
    HERRNRING, C
    HOFFMANN, T
    ZANDER, AR
    KOHLSCHUTTER, A
    EXPERIMENTAL HEMATOLOGY, 1995, 23 (08) : 861 - 861
  • [48] Bleomycin-detectable iron assay for non-transferrin-bound iron in hematologic malignancies
    von Bonsdorff, L
    Lindeberg, E
    Sahlstedt, L
    Lehto, J
    Parkkinen, J
    CLINICAL CHEMISTRY, 2002, 48 (02) : 307 - 314
  • [49] REMOVAL OF NON-TRANSFERRIN-BOUND IRON WITH IMMOBILIZED DESFERRIOXAMINE, FROM BLOOD WITH IRON OVERLOAD
    AMBRUS, CM
    STADLER, I
    TOUMBIS, CA
    STADLER, A
    ANTHONE, S
    DEALARCON, P
    DESHPANDE, G
    CONWAY, J
    VLADUTIU, AL
    BLOOD, 1993, 82 (10) : A359 - A359
  • [50] Nature of non-transferrin-bound iron: studies on iron citrate complexes and thalassemic sera
    Robert W. Evans
    Roozina Rafique
    Adel Zarea
    Chiara Rapisarda
    Richard Cammack
    Patricia J. Evans
    John B. Porter
    Robert C. Hider
    JBIC Journal of Biological Inorganic Chemistry, 2008, 13 : 57 - 74
12345