Non-transferrin-bound iron takes the driver's seat

被引：5
|
作者：
Knutson, Mitchell D. [1 ]
机构：
[1] Univ Florida, Gainesville, FL 32611 USA
来源：
BLOOD | 2023年 / 141卷 / 03期
关键词：
D O I：
10.1182/blood.2022019049
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In this issue of Blood, Charlebois et al(1) report that non-transferrin-bound iron (NTBI) is the primary driver of bone morphogenetic protein 6 (BMP6) expression in liver sinusoidal endothelial cells (LSECs) during iron overload. This finding is important because LSEC-derived BMP6 prompts the liver to produce hepcidin, the chief iron-regulatory hormone that regulates body iron balance.
引用
收藏
页码：214 / 216
页数：3
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