Three new chromanes and one new flavone C-glycoside from Mallotus apelta

Three new chromanes, malloapeltas J-L (1-3), and one new flavone C-glycoside, malloflavoside (4), together with four known compounds, apigenin 6-C-beta-D-xylopyranosyl-8-C-alpha-L-arabinopyranoside (5), apigenin 6-C-beta-D-glucopyranosyl-8-C-alpha-L-arabinopyranoside (6), apigenin 7-O-beta-D-apiofuranosyl-(1 -> 2)-beta-D-glucopyranoside (7), and acantrifoside E (8) were isolated from the methanol extract of the leaves of Mallotus apelta. Their chemical structures were determined using spectroscopic methods, including 1D, 2D NMR, and HR-ESI-MS methods. All the isolated compounds were evaluated their cytotoxic activity against human prostate cancer (PC-3) and human breast cancer (MCF-7) cells, but none of them showed cytotoxicities on both human cancer cell lines.