KF-catalyzed direct thiomethylation of carboxylic acids with DMSO to access methyl thioesters

被引：0

作者：

Huang, Ding-Yong ^{[1
,2
]}

Liu, Hong-Shi ^{[1
,2
]}

Wang, En-Hua ^{[3
]}

Peng, Mei ^{[1
,2
]}

Deng, Ting-Fei ^{[1
,2
]}

Gao, Ming ^{[1
,2
]}

Liu, Sheng ^{[1
,2
]}

Li, Qi-Ji ^{[1
,2
]}

Yang, Li-Shou ^{[1
,2
]}

Yang, Xiao-Sheng ^{[1
,2
]}

机构：

[1] Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Peoples R China

[2] Nat Prod Res Ctr Guizhou Prov, Guiyang 550014, Peoples R China

[3] Guizhou Vocat Coll Agr, Dept Med & Food, Guiyang 550041, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2024年 / 22卷 / 07期

基金：

中国国家自然科学基金;

关键词：

DIMETHYL-SULFOXIDE; EFFICIENT SYNTHESIS; COUPLING REACTION; FACILE SYNTHESIS; ARYL IODIDES; ALDEHYDES; THIOESTERIFICATION; THIOCARBONYLATION; CARBONYLATION; KETONES;

D O I：

10.1039/d3ob01991h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

With dimethyl sulfoxide (DMSO) as the methylthio source, a KF-catalyzed strategy was employed for the direct thiomethylation of carboxylic acids with DMSO for the preparation of methyl thioesters. In this process, a wide range of methyl thioesters were obtained in moderate to excellent yields. This novel strategy features the first use of DMSO as a methylthiolating agent for the construction of methyl thioesters, transition metal-free conditions, inexpensive reagents, easy workup, broad substrate scope and sustainability. Additionally, this procedure can be readily scaled up to a gram scale. A transition metal-free, KF-catalyzed synthesis of methyl thioesters has been developed via the direct thiomethylation of carboxylic acids with DMSO.

引用

页码：1453 / 1457

页数：5

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