Access to α,α-dithioketones through direct di-sulfenylation of methyl ketones mediated by KOH-DMSO system

被引：3
|
作者：
Duan, Bobo [1 ]
Li, Huijuan [1 ]
Chen, Yu [1 ]
Xu, Cheng [1 ]
Yin, Guodong [1 ]
机构：
[1] Hubei Normal Univ, Coll Chem & Chem Engn, Hubei Key Lab Pollutant Anal & Reuse Technol, Huangshi 435002, Peoples R China
来源：
TETRAHEDRON LETTERS | 2022年 / 94卷
关键词：
alpha; alpha-Dithioketones; Di-sulfenylation; Methyl ketones; C-S bond formation; KOH-DMSO superbase; S BOND FORMATION; BIS-SULFENYLATION; TRIFLUOROMETHYLTHIOLATION; ESTERS;
D O I：
10.1016/j.tetlet.2022.153697
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A direct di-sulfenylation of methyl ketones with disulfides mediated by KOH-DMSO superbase system has been developed. This reaction provides an efficient route to alpha,alpha-dithioketones, which has the advantages of readily available non-prefunctionalized substrates, good functional group tolerance, excellent yields as well as high selectivity. In a single operation, two C-S bonds are simultaneously built on the same carbon atom under mild reaction conditions.(c) 2022 Elsevier Ltd. All rights reserved.
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页数：4
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