Sequence based HLA-DRB1,-DQB1 and-DPB1 allele and haplotype frequencies in The Gambia

被引：0
|
作者：
Barton, Amber [1 ]
Pickering, Harry [1 ]
Payne, Thomas [1 ]
Faal, Nkoyo [2 ]
Sillah, Ansumana [3 ]
Harte, Anna [1 ]
Bailey, Robin L. [1 ]
Mabey, David C. W. [1 ]
Roberts, Chrissy H. [1 ]
Holland, Martin J. [1 ,2 ,4 ]
机构：
[1] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Clin Res Dept, Keppel St, London WC1E 7HT, England
[2] Med Res Council Gambia LSHTM, Atlantic Blvd, Fajara, Banjul, Gambia
[3] Natl Eye Hlth Programme, Minist Hlth, Banjul, Gambia
[4] Clin Res Dept, ITD, LSHTM, London, England
来源：
HUMAN IMMUNOLOGY | 2023年 / 84卷 / 02期
基金：
欧盟地平线“2020”; 英国惠康基金;
关键词：
HLA; MHC; Gambia; Immunogenetics; Mandinka; Fula; Wolof; Jola; EXPRESSION; TRACHOMA;
D O I：
10.1016/j.humimm.2022.10.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Class II HLA loci DRB1, DQB1 and DPB1 were typed for a total of 939 Gambian participants by locus-specific amplicon sequencing. Participants were from multiple regions of The Gambia and drawn from two studies: a family study aiming to identify associations between host genotype and trachomatous scarring (N = 796) and a cohort study aiming to identify correlates of immunity to trachoma (N = 143). All loci deviated from HardyWeinberg equilibrium, likely due to the family-based nature of the study: 608 participants had at least one other family member included in the study population. The most common alleles for HLA-DRB1, DQB1 and DPB1 respectively were DRB1*13:04 (18.8 %), DQB1*03:19 (27.9 %) and DPB1*01:01 (25.4 %). Participants belonged to a variety of ethnicities, including the Mandinka, Fula, Wolof and Jola ethnic groups.
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页码：69 / 70
页数：2
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