Sequence based HLA-DRB1,-DQB1 and-DPB1 allele and haplotype frequencies in The Gambia

被引：0

作者：

Barton, Amber ^{[1
]}

Pickering, Harry ^{[1
]}

Payne, Thomas ^{[1
]}

Faal, Nkoyo ^{[2
]}

Sillah, Ansumana ^{[3
]}

Harte, Anna ^{[1
]}

Bailey, Robin L. ^{[1
]}

Mabey, David C. W. ^{[1
]}

Roberts, Chrissy H. ^{[1
]}

Holland, Martin J. ^{[1
,2
,4
]}

机构：

[1] London Sch Hyg & Trop Med, Fac Infect & Trop Dis, Clin Res Dept, Keppel St, London WC1E 7HT, England

[2] Med Res Council Gambia LSHTM, Atlantic Blvd, Fajara, Banjul, Gambia

[3] Natl Eye Hlth Programme, Minist Hlth, Banjul, Gambia

[4] Clin Res Dept, ITD, LSHTM, London, England

来源：

HUMAN IMMUNOLOGY | 2023年 / 84卷 / 02期

基金：

欧盟地平线“2020”; 英国惠康基金;

关键词：

HLA; MHC; Gambia; Immunogenetics; Mandinka; Fula; Wolof; Jola; EXPRESSION; TRACHOMA;

D O I：

10.1016/j.humimm.2022.10.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Class II HLA loci DRB1, DQB1 and DPB1 were typed for a total of 939 Gambian participants by locus-specific amplicon sequencing. Participants were from multiple regions of The Gambia and drawn from two studies: a family study aiming to identify associations between host genotype and trachomatous scarring (N = 796) and a cohort study aiming to identify correlates of immunity to trachoma (N = 143). All loci deviated from HardyWeinberg equilibrium, likely due to the family-based nature of the study: 608 participants had at least one other family member included in the study population. The most common alleles for HLA-DRB1, DQB1 and DPB1 respectively were DRB1*13:04 (18.8 %), DQB1*03:19 (27.9 %) and DPB1*01:01 (25.4 %). Participants belonged to a variety of ethnicities, including the Mandinka, Fula, Wolof and Jola ethnic groups.

引用

页码：69 / 70

页数：2

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