Studies on repairing of hemisected thoracic spinal cord of adult rats by using a chitosan tube filled with alginate fibers

被引：1
|
作者：
LI Xiaoguang
Department of Bioengineering
National Center of Biomedical Analysis
机构：
来源：
ProgressinNaturalScience | 2006年 / 10期
基金：
中国国家自然科学基金;
关键词：
spinal cord injury; regeneration; function recovery; chitosan; alginate; behavioral evaluation;
D O I：
暂无
中图分类号：
Q95-33 [动物学实验（实验动物学）、动物学技术];
学科分类号：
071002 ;
摘要：
A chitosan tube filled with alginate fibers was implanted into the injured spinal cord of a rat for repairing the damaged tissue. Twelve months after the operation, the morphological observation demonstrated that this chitosan tube could induce regeneration of myelinated and non-myelinated axons and blood vessels. The Basso-Beattie-Bresnahan (BBB) behavioral evaluation confirmed that the implants played a key role in the long-term restoration of rats motor functions. It is a promising start in the treatment of the patients with the injury of the spinal cord.
引用
收藏
页码：1051 / 1055
页数：5
相关论文
共 45 条
  • [41] IMMUNO-ELECTRON-MICROSCOPIC STUDIES ON THE GAMMA-AMINOBUTYRIC-ACID AND GLYCINE RECEPTOR IN THE INTERMEDIOLATERAL NUCLEUS OF THE THORACIC SPINAL-CORD OF RATS AND GUINEA-PIGS
    CHIBA, T
    SEMBA, R
    JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1991, 36 (03): : 173 - 182
  • [42] Extended magnetic resonance imaging studies on the effect of classically activated microglia transplantation on white matter regeneration following spinal cord focal injury in adult rats
    Marcol, Wieslaw
    Slusarczyk, Wojciech
    Larysz-Brysz, Magdalena
    Labuzek, Krzysztof
    Kapustka, Bartosz
    Staszkiewicz, Rafal
    Rosicka, Paulina
    Kalita, Katarzyna
    Weglarz, Wladyslaw
    Lewin-Kowalik, Joanna
    EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 14 (05) : 4869 - 4877
  • [43] GRAFTS OF SYNGENIC CULTURED, ADULT DORSAL-ROOT GANGLION-DERIVED SCHWANN-CELLS TO THE INJURED SPINAL-CORD OF ADULT-RATS - PRELIMINARY MORPHOLOGICAL-STUDIES
    MARTIN, D
    SCHOENEN, J
    DELREE, P
    LEPRINCE, P
    ROGISTER, B
    MOONEN, G
    NEUROSCIENCE LETTERS, 1991, 124 (01) : 44 - 48
  • [44] FATE OF B1-B2 AND B3 RHOMBENCEPHALIC CELLS TRANSPLANTED INTO THE TRANSECTED SPINAL-CORD OF ADULT-RATS - LIGHT AND ELECTRON-MICROSCOPIC STUDIES
    RAJAOFETRA, N
    KONIG, N
    POULAT, P
    MARLIER, L
    SANDILLON, F
    DRIAN, MJ
    GEFFARD, M
    PRIVAT, A
    EXPERIMENTAL NEUROLOGY, 1992, 117 (01) : 59 - 70
  • [45] Brain Derived Neurotrophic Factor (BDNF) Immunolabeling in C4-05 Spinal Cord of Adult Female Rats Following Acute Intermittent Hypoxia (AIH) Exposure Composed of 5,3-min Hypoxic Episodes (AIH5x3min) at 4-weeks After mid -thoracic SCI
    Zhong, Amanda
    Solomon, Irene C.
    PHYSIOLOGY, 2024, 39
12345