Identification of prognostic biomarkers for cholangiocarcinoma by combined analysis of molecular characteristics of clinical MVI subtypes and molecular subtypes

被引：0

作者：

Li, Ming-Yue ^{[1
]}

Liu, Ya-Hui ^{[1
]}

Wei, Feng ^{[1
]}

Zhang, Ping ^{[1
]}

Sun, Xiao-Dong ^{[1
]}

Wang, Meng ^{[1
]}

Du, Xiao-Hong ^{[1
]}

Ye, Jun-Feng ^{[1
]}

Qiu, Wei ^{[1
]}

Shi, Xiao-Ju ^{[1
]}

Ji, Bai ^{[1
]}

Wang, Ying-Chao ^{[1
]}

Jiang, Chao ^{[1
]}

Chai, Wen-Gang ^{[1
]}

Huang, Bo ^{[1
]}

Liu, Xing-Kai ^{[1
]}

Chen, Qing-Min ^{[1
]}

Fu, Yu ^{[1
]}

Hu, Xin-Tong ^{[2
]}

Chen, Li-Guo ^{[2
]}

He, Jia-Xue ^{[2
]}

Chai, Kai-Yuan ^{[1
]}

Gou, Zhao-Ming ^{[1
]}

Yang, Tian ^{[1
,3
]}

Wang, Guang-Yi ^{[1
]}

Jiang, Yan-Fang ^{[2
]}

Fan, Zhong-Qi ^{[1
]}

Lv, Guo-Yue ^{[1
]}

机构：

[1] Jilin Univ, Gen Surg Ctr, Dept Hepatobiliary & Pancreat Surg, Hosp 1, 1 Xinmin St, Changchun 130021, Jilin, Peoples R China

[2] Jilin Univ, Genet Diag Ctr, Key Lab Organ Regenerat & Transplantat, Minist Educ,Hosp 1, 1 Xinmin St, Changchun 130021, Jilin, Peoples R China

[3] Navy Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepatobiliary Surg, Mil Med Univ 2, Shanghai, Peoples R China

来源：

GENOMICS | 2024年 / 116卷 / 05期

关键词：

Cholangiocarcinoma; MVI; Molecular classification; Prognostic marker; INTRAHEPATIC CHOLANGIOCARCINOMA; CLASSIFICATION;

D O I：

10.1016/j.ygeno.2024.110889

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cholangiocarcinoma (CCA) is widely noted for its high degree of malignancy, rapid progression, and limited therapeutic options. This study was carried out on transcriptome data of 417 CCA samples from different anatomical locations. The effects of lipid metabolism related genes and immune related genes as CCA classifiers were compared. Key genes were derived from MVI subtypes and better molecular subtypes. Pathways such as epithelial mesenchymal transition (EMT) and cell cycle were significantly activated in MVI-positive group. CCA patients were classified into three (four) subtypes based on lipid metabolism (immune) related genes, with better prognosis observed in lipid metabolism-C1, immune-C2, and immune-C4. IPTW analysis found that the prognosis of lipid metabolism-C1 was significantly better than that of lipid metabolism-C2 + C3 before and after correction. KRT16 was finally selected as the key gene. And knockdown of KRT16 inhibited proliferation, migration and invasion of CCA cells.

引用

页数：16

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