Identification of prognostic biomarkers for cholangiocarcinoma by combined analysis of molecular characteristics of clinical MVI subtypes and molecular subtypes

被引：0

作者：

Li, Ming-Yue ^{[1
]}

Liu, Ya-Hui ^{[1
]}

Wei, Feng ^{[1
]}

Zhang, Ping ^{[1
]}

Sun, Xiao-Dong ^{[1
]}

Wang, Meng ^{[1
]}

Du, Xiao-Hong ^{[1
]}

Ye, Jun-Feng ^{[1
]}

Qiu, Wei ^{[1
]}

Shi, Xiao-Ju ^{[1
]}

Ji, Bai ^{[1
]}

Wang, Ying-Chao ^{[1
]}

Jiang, Chao ^{[1
]}

Chai, Wen-Gang ^{[1
]}

Huang, Bo ^{[1
]}

Liu, Xing-Kai ^{[1
]}

Chen, Qing-Min ^{[1
]}

Fu, Yu ^{[1
]}

Hu, Xin-Tong ^{[2
]}

Chen, Li-Guo ^{[2
]}

He, Jia-Xue ^{[2
]}

Chai, Kai-Yuan ^{[1
]}

Gou, Zhao-Ming ^{[1
]}

Yang, Tian ^{[1
,3
]}

Wang, Guang-Yi ^{[1
]}

Jiang, Yan-Fang ^{[2
]}

Fan, Zhong-Qi ^{[1
]}

Lv, Guo-Yue ^{[1
]}

机构：

[1] Jilin Univ, Gen Surg Ctr, Dept Hepatobiliary & Pancreat Surg, Hosp 1, 1 Xinmin St, Changchun 130021, Jilin, Peoples R China

[2] Jilin Univ, Genet Diag Ctr, Key Lab Organ Regenerat & Transplantat, Minist Educ,Hosp 1, 1 Xinmin St, Changchun 130021, Jilin, Peoples R China

[3] Navy Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepatobiliary Surg, Mil Med Univ 2, Shanghai, Peoples R China

来源：

GENOMICS | 2024年 / 116卷 / 05期

关键词：

Cholangiocarcinoma; MVI; Molecular classification; Prognostic marker; INTRAHEPATIC CHOLANGIOCARCINOMA; CLASSIFICATION;

D O I：

10.1016/j.ygeno.2024.110889

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cholangiocarcinoma (CCA) is widely noted for its high degree of malignancy, rapid progression, and limited therapeutic options. This study was carried out on transcriptome data of 417 CCA samples from different anatomical locations. The effects of lipid metabolism related genes and immune related genes as CCA classifiers were compared. Key genes were derived from MVI subtypes and better molecular subtypes. Pathways such as epithelial mesenchymal transition (EMT) and cell cycle were significantly activated in MVI-positive group. CCA patients were classified into three (four) subtypes based on lipid metabolism (immune) related genes, with better prognosis observed in lipid metabolism-C1, immune-C2, and immune-C4. IPTW analysis found that the prognosis of lipid metabolism-C1 was significantly better than that of lipid metabolism-C2 + C3 before and after correction. KRT16 was finally selected as the key gene. And knockdown of KRT16 inhibited proliferation, migration and invasion of CCA cells.

引用

页数：16

共 50 条

[21] Clinical prognostic evaluation of immunocytes in different molecular subtypes of breast cancer
Huang Zenan
Li Zixiong
Yao Zhicheng
Huang Mei
Yang Xiongbin
Wang Tiantian
Dong Min
Liu Renbin
Jia Changchang
JOURNAL OF CELLULAR PHYSIOLOGY, 2019, 234 (11) : 20584 - 20602
[22] Prognostic Value of Molecular Subtypes in Pancreatic Cancer
Bertucci, Francois
Birnbaum, David J.
Finetti, Pascal
Gilabert, Marine
Poizat, Flora
Raoul, Jean-Luc
Birnbaum, Daniel
Mamessier, Emilie
PANCREAS, 2017, 46 (04) : E29 - E31
[23] Identification of adipokine-related gene-based molecular subtypes of colon cancer and prognostic characteristics
Li, Weidong
Xu, Jincheng
Wen, Zhengchao
Zhong, Qixing
Deng, Naisheng
Sun, Xueying
Jiang, Yanan
Wang, Yao
COLORECTAL CANCER, 2024, 13 (01)
[24] Identification of biomarkers related to neutrophils and two molecular subtypes of systemic lupus erythematosus
Huiyan Li
Pingting Yang
BMC Medical Genomics, 15
[25] Identification of biomarkers related to neutrophils and two molecular subtypes of systemic lupus erythematosus
Li, Huiyan
Yang, Pingting
BMC MEDICAL GENOMICS, 2022, 15 (01)
[26] Identification of gut microbes-related molecular subtypes and their biomarkers in colorectal cancer
Liu, Xuliang
Zhang, Guolin
Li, Shiyao
Liu, Yuechuan
Ma, Kexin
Wang, Liming
AGING-US, 2024, 16 (03): : 2249 - 2272
[27] Clinical implications of the intrinsic molecular subtypes
Prat, A.
BREAST, 2015, 24 : S5 - S6
[28] Identification of molecular subtypes premised on the characteristics of immune infiltration of endometrial cancer
Liu, Cong
Zhang, Yan
Hang, Chen
ANNALS OF TRANSLATIONAL MEDICINE, 2022, 10 (06)
[29] Identification of Immune-Related lncRNA Prognostic Signature and Molecular Subtypes for Glioblastoma
Yu, Wanli
Ma, Yanan
Hou, Wenbin
Wang, Fang
Cheng, Wan
Qiu, Feng
Wu, Pengfei
Zhang, Guohua
FRONTIERS IN IMMUNOLOGY, 2021, 12
[30] Identification of a molecular signature of prognostic subtypes in diffuse-type gastric cancer
Kim, Seon-Kyu
Kim, Hee-Jin
Park, Jong-Lyul
Heo, Haejeong
Kim, Seon-Young
Lee, Sang-Il
Song, Kyu-Sang
Kim, Woo-Ho
Kim, Yong Sung
GASTRIC CANCER, 2020, 23 (03) : 473 - 482

← 1 2 3 4 5 →