Identification of prognostic biomarkers for cholangiocarcinoma by combined analysis of molecular characteristics of clinical MVI subtypes and molecular subtypes

被引：0

作者：

Li, Ming-Yue ^{[1
]}

Liu, Ya-Hui ^{[1
]}

Wei, Feng ^{[1
]}

Zhang, Ping ^{[1
]}

Sun, Xiao-Dong ^{[1
]}

Wang, Meng ^{[1
]}

Du, Xiao-Hong ^{[1
]}

Ye, Jun-Feng ^{[1
]}

Qiu, Wei ^{[1
]}

Shi, Xiao-Ju ^{[1
]}

Ji, Bai ^{[1
]}

Wang, Ying-Chao ^{[1
]}

Jiang, Chao ^{[1
]}

Chai, Wen-Gang ^{[1
]}

Huang, Bo ^{[1
]}

Liu, Xing-Kai ^{[1
]}

Chen, Qing-Min ^{[1
]}

Fu, Yu ^{[1
]}

Hu, Xin-Tong ^{[2
]}

Chen, Li-Guo ^{[2
]}

He, Jia-Xue ^{[2
]}

Chai, Kai-Yuan ^{[1
]}

Gou, Zhao-Ming ^{[1
]}

Yang, Tian ^{[1
,3
]}

Wang, Guang-Yi ^{[1
]}

Jiang, Yan-Fang ^{[2
]}

Fan, Zhong-Qi ^{[1
]}

Lv, Guo-Yue ^{[1
]}

机构：

[1] Jilin Univ, Gen Surg Ctr, Dept Hepatobiliary & Pancreat Surg, Hosp 1, 1 Xinmin St, Changchun 130021, Jilin, Peoples R China

[2] Jilin Univ, Genet Diag Ctr, Key Lab Organ Regenerat & Transplantat, Minist Educ,Hosp 1, 1 Xinmin St, Changchun 130021, Jilin, Peoples R China

[3] Navy Med Univ, Eastern Hepatobiliary Surg Hosp, Dept Hepatobiliary Surg, Mil Med Univ 2, Shanghai, Peoples R China

来源：

GENOMICS | 2024年 / 116卷 / 05期

关键词：

Cholangiocarcinoma; MVI; Molecular classification; Prognostic marker; INTRAHEPATIC CHOLANGIOCARCINOMA; CLASSIFICATION;

D O I：

10.1016/j.ygeno.2024.110889

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cholangiocarcinoma (CCA) is widely noted for its high degree of malignancy, rapid progression, and limited therapeutic options. This study was carried out on transcriptome data of 417 CCA samples from different anatomical locations. The effects of lipid metabolism related genes and immune related genes as CCA classifiers were compared. Key genes were derived from MVI subtypes and better molecular subtypes. Pathways such as epithelial mesenchymal transition (EMT) and cell cycle were significantly activated in MVI-positive group. CCA patients were classified into three (four) subtypes based on lipid metabolism (immune) related genes, with better prognosis observed in lipid metabolism-C1, immune-C2, and immune-C4. IPTW analysis found that the prognosis of lipid metabolism-C1 was significantly better than that of lipid metabolism-C2 + C3 before and after correction. KRT16 was finally selected as the key gene. And knockdown of KRT16 inhibited proliferation, migration and invasion of CCA cells.

引用

页数：16

共 50 条

[1] Molecular subtypes of breast cancer: prognostic implications and clinical and immunohistochemical characteristics
Arrechea Irigoyen, M. A.
Vicente Garcia, F.
Cordoba Iturriagagoitia, A.
Ibanez Beroiz, B.
Santamaria Martinez, M.
Guillien Grima, F.
ANALES DEL SISTEMA SANITARIO DE NAVARRA, 2011, 34 (02) : 219 - 233
[2] Identification of molecular subtypes based on bile acid metabolism in cholangiocarcinoma
Deng, Mingxia
Liu, Jing
Zhang, Li
Lou, Yan
Qiu, Yunqing
BMC CANCER, 2024, 24 (01)
[3] Survival analysis and molecular discrimination of cholangiocarcinoma anatomical subtypes
Tavares, Ines
Ribeiro, Ilda P.
Martins, Ricardo
Esteves, Luisa
Abrantes, Margarida
Botelho, Maria Filomena
Tralhao, Jose G.
Melo, Joana B.
Carreira, Isabel M.
MEDICINE, 2020, 99 (23)
[4] Identification of Molecular Subtypes and Prognostic Characteristics of Adrenocortical Carcinoma Based on Unsupervised Clustering
Zhang, Yuan
Zhang, Cong
Li, Kangjie
Deng, Jielian
Liu, Hui
Lai, Guichuan
Xie, Biao
Zhong, Xiaoni
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (20)
[5] Identification of Clinical Relevant Molecular Subtypes of Pheochromocytoma
Saddozai, Umair Ali Khan
Wang, Fengling
Akbar, Muhammad Usman
Zhang, Lu
An, Yang
Zhu, Wan
Xie, Longxiang
Li, Yongqiang
Ji, Xinying
Guo, Xiangqian
FRONTIERS IN ENDOCRINOLOGY, 2021, 12
[6] Clinical And Molecular Pathological Characteristics As Prognostic Indicators Of Histological Subtypes Of Lung Adenocarcinoma
Mu, X.
Liu, Q.
Du, J.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2011, 183
[7] Molecular Subtypes and Precision Oncology in Intrahepatic Cholangiocarcinoma
Czauderna, Carolin
Kirstein, Martha M.
Tews, Hauke C.
Vogel, Arndt
Marquardt, Jens U.
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (13)
[8] Circulating MicroRNAs as Prognostic and Therapeutic Biomarkers in Breast Cancer Molecular Subtypes
Zelli, Veronica
Compagnoni, Chiara
Capelli, Roberta
Cannita, Katia
Sidoni, Tina
Ficorella, Corrado
Capalbo, Carlo
Zazzeroni, Francesca
Tessitore, Alessandra
Alesse, Edoardo
JOURNAL OF PERSONALIZED MEDICINE, 2020, 10 (03): : 1 - 18
[9] Clinical Subtypes and Molecular Characteristics of Serrated Polyposis Syndrome
Guarinos, Carla
Sanchez-Fortun, Cristina
Rodriguez-Soler, Maria
Perez-Carbonell, Lucia
Egoavil, Cecilia
Juarez, Miriam
Serradesanferm, Anna
Bujanda, Luis
Fernandez-Banares, Fernando
Cubiella, Joaquin
De-Castro, Luisa
Guerra, Ana
Aguirre, Elena
Herreros-De-Tejada, Alberto
Bessa, Xavier
Herraiz, Maite
Marin-Gabriel, Jose-Carlos
Balmana, Judith
Cuatrecasas, Miriam
Balaguer, Francesc
Castells, Antoni
Soto, Jose-Luis
Alenda, Cristina
Paya, Artemio
Jover, Rodrigo
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY, 2013, 11 (06) : 705 - 711
[10] Clinical and molecular characteristics of bladder urothelial carcinoma subtypes
Li, Ying
Yang, Kai
Li, Ke
Liu, He
Zhao, Siqi
Jiao, Mingli
Fu, Xinru
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (06) : 9956 - 9963

← 1 2 3 4 5 →