The role of heart and neural crest derivatives-expressed protein factors in pregnancy

被引：0
|
作者：
Zhu, Chongying [1 ,2 ]
Yang, Qiwei [3 ]
Xu, Qiang [1 ]
Song, Yanhua [4 ]
Tang, Chao [1 ]
机构：
[1] Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Sch Med, Hangzhou 310052, Peoples R China
[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Obstet & Gynecol, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
[3] Tongji Univ, Shanghai East Hosp, Sch Med, Dept Urol, Shanghai 200100, Peoples R China
[4] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2025年 / 1871卷 / 03期
基金：
中国国家自然科学基金;
关键词：
HAND; Pregnancy; Placenta; Fetal development; Gestational complications; TRANSCRIPTION FACTOR; HAND1; PHOSPHOREGULATION; CELL-DIFFERENTIATION; MOUSE; GENE; REGULATORS; CONVERSION; BINDING; ARCH;
D O I：
10.1016/j.bbadis.2024.167639
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Heart and neural crest derivatives-expressed protein 1 (HAND1) and Heart and neural crest derivatives-expressed protein 2 (HAND2), members of the Twist-family of basic Helix-Loop-Helix (bHLH) proteins, act as critical transcription factors that play a key role in various developmental processes, including placental development and fetal growth during pregnancy. This review aims to explore the current understanding of HAND1 and HAND2 in pregnant maintenance and their potential implications for maternal and fetal health. We will summarize the mechanisms of action of HAND1 and HAND2 in pregnancy, their expression regulation and association with pregnancy complications such as preterm birth and preeclampsia. Furthermore, we will discuss the potential therapeutic implications of targeting HAND1 and HAND2 in pregnancy-related disorders. This review highlights the importance of HAND1 and HAND2 in pregnancy and their potential as targets for future research and therapeutic interventions of gestational disorders.
引用
收藏
页数：6
相关论文
共 50 条
  • [41] Green fluorescent protein used to assess cranial neural crest derivatives in the frog, Xenopus laevis
    Carl, TF
    Vourgourakis, Y
    Klymkowsky, MW
    Hanken, J
    REGULATORY PROCESSES IN DEVELOPMENT, 2000, 76 : 167 - 172
  • [42] ROLE OF EXTRINSIC FACTORS IN THE DEVELOPMENT OF THE PERIPHERAL NERVOUS-SYSTEM FROM THE NEURAL CREST
    SMITH, J
    BAROFFIO, A
    DUPIN, E
    KALCHEIM, C
    LEDOUARIN, NM
    XUE, ZG
    PERIPHERAL NERVE DEVELOPMENT AND REGENERATION: RECENT ADVANCES AND CLINICAL APPLICATIONS, 1989, 19 : 3 - 11
  • [43] Protein Kinase 2β Is Expressed in Neural Crest-Derived Urinary Pacemaker Cells and Required for Pyeloureteric Contraction
    Iskander, Samir M.
    Feeney, Meghan M.
    Yee, Kirby
    Rosenblum, Norman D.
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2018, 29 (04): : 1198 - 1209
  • [44] Frizzled 2 is transiently expressed in neural crest-containing areas during development of the heart and great arteries in the mouse
    van Gijn, ME
    Blankesteijn, WM
    Smits, JFM
    Hierck, B
    Gittenberger-de Groot, AC
    ANATOMY AND EMBRYOLOGY, 2001, 203 (03): : 185 - 192
  • [45] Frizzled 2 is transiently expressed in neural crest-containing areas during development of the heart and great arteries in the mouse
    M. E. van Gijn
    W. M. Blankesteijn
    Jos F. M. Smits
    Beerend Hierck
    A. C. Gittenberger-de Groot
    Anatomy and Embryology, 2001, 203 : 185 - 192
  • [46] Islet1 Derivatives in the Heart Are of Both Neural Crest and Second Heart Field Origin (vol 110, pg 922, 2012)
    Engleka, K. A.
    CIRCULATION RESEARCH, 2012, 110 (11) : E90 - E90
  • [47] Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects
    Arrigo, Angelo B.
    Lin, Jiuann-Huey Ivy
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (16)
  • [48] ENVIRONMENTAL-INFLUENCES IN THE DEVELOPMENT OF NEURAL CREST DERIVATIVES - GLUCOCORTICOIDS, GROWTH-FACTORS, AND CHROMAFFIN CELL PLASTICITY
    DOUPE, AJ
    LANDIS, SC
    PATTERSON, PH
    JOURNAL OF NEUROSCIENCE, 1985, 5 (08): : 2119 - 2142
  • [49] HERG- and IRK-like inward rectifier currents are sequentially expressed during neuronal development of neural crest cells and their derivatives
    Arcangeli, A
    Rosati, B
    Cherubini, A
    Crociani, O
    Fontana, L
    Ziller, C
    Wanke, E
    Olivotto, M
    EUROPEAN JOURNAL OF NEUROSCIENCE, 1997, 9 (12) : 2596 - 2604
  • [50] Role of noggin as an upstream signal in the lack of neuronal derivatives found in the avian caudal-most neural crest
    Osorio, Liliana
    Teillet, Marie-Aimee
    Catala, Martin
    DEVELOPMENT, 2009, 136 (10): : 1717 - 1726
12345