The role of heart and neural crest derivatives-expressed protein factors in pregnancy

被引：0
|
作者：
Zhu, Chongying [1 ,2 ]
Yang, Qiwei [3 ]
Xu, Qiang [1 ]
Song, Yanhua [4 ]
Tang, Chao [1 ]
机构：
[1] Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Sch Med, Hangzhou 310052, Peoples R China
[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Obstet & Gynecol, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China
[3] Tongji Univ, Shanghai East Hosp, Sch Med, Dept Urol, Shanghai 200100, Peoples R China
[4] Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2025年 / 1871卷 / 03期
基金：
中国国家自然科学基金;
关键词：
HAND; Pregnancy; Placenta; Fetal development; Gestational complications; TRANSCRIPTION FACTOR; HAND1; PHOSPHOREGULATION; CELL-DIFFERENTIATION; MOUSE; GENE; REGULATORS; CONVERSION; BINDING; ARCH;
D O I：
10.1016/j.bbadis.2024.167639
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Heart and neural crest derivatives-expressed protein 1 (HAND1) and Heart and neural crest derivatives-expressed protein 2 (HAND2), members of the Twist-family of basic Helix-Loop-Helix (bHLH) proteins, act as critical transcription factors that play a key role in various developmental processes, including placental development and fetal growth during pregnancy. This review aims to explore the current understanding of HAND1 and HAND2 in pregnant maintenance and their potential implications for maternal and fetal health. We will summarize the mechanisms of action of HAND1 and HAND2 in pregnancy, their expression regulation and association with pregnancy complications such as preterm birth and preeclampsia. Furthermore, we will discuss the potential therapeutic implications of targeting HAND1 and HAND2 in pregnancy-related disorders. This review highlights the importance of HAND1 and HAND2 in pregnancy and their potential as targets for future research and therapeutic interventions of gestational disorders.
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页数：6
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