The regulating role of galectin-9 in immune cell populations

被引:0
|
作者
Cao, Zhanqi [1 ]
Leng, Ping [1 ]
Xu, Hanlin [1 ]
Li, Xiangpeng [1 ]
机构
[1] Qingdao Univ, Dept Pharm, Affiliated Hosp, Qingdao, Peoples R China
关键词
galectin-9; immune; T cell; strategies; inhibitors; NATURAL-KILLER-CELLS; T-CELLS; EOSINOPHIL CHEMOATTRACTANT; PROGNOSTIC-SIGNIFICANCE; DIVERSE ROLES; SERUM-LEVELS; ACTIVATION; EXPRESSION; TIM-3; IMMUNOGLOBULIN;
D O I
10.3389/fphar.2024.1462061
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Galectin-9 (gal-9) is a protein that belongs to the galectin family. Gal-9 is expressed in cells of the innate and adaptive immune system, including lymphocytes, dendritic cells, giant salivary cells, eosinophils and T cells, etc. In different immune cells, the role of gal-9 is different. Gal-9 can induce the proliferation and activation of immune cells, and also promote the apoptosis of immune cells. This effect of gal-9 affects the occurrence and development of a variety of immune-related diseases, such as the invasion of pathogenic microorganisms, immune escape of tumor cells, and inflammatory response. Thus, understanding the biological roles of gal-9 in innate and adaptive immunity may be essential for autoimmune diseases treatment and diagnosis to improve patient quality of life. In this review, we aim to summarize current research on the regulatory roles of gal-9 in human immune system and potential inducers and inhibitors of gal-9, which may provide new strategies for immune diseases therapies.
引用
收藏
页数:10
相关论文
共 50 条
  • [41] Novel role for galectin-9 as a potent inhibitor of human cytomegalovirus infection
    Machala, E. A.
    McSharry, B. P.
    Abendroth, A.
    Slobedman, B.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 679 - 679
  • [42] Glial galectin-9 plays anovel role inhypoxic tumor environment
    Change, Chi Young
    Baek, Seungtae
    Kim, Hyung-Seok
    Jeon, Sae-Bom
    Johnson, Randall S.
    Park, Eun Jung
    CYTOKINE, 2017, 100 : 190 - 190
  • [43] Possible role of galectin-9 in lipopolysaccharide-induced peritonitis in mouse
    Abe, H
    Nakagawa, R
    Nishi, N
    Yamauchi, A
    Hirashima, M
    GLYCOBIOLOGY, 2004, 14 (11) : 1166 - 1166
  • [44] Characteristic immunomodulatory role of myeloid galectin-9 in the brain tumor microenvironment
    Lee, Chanju
    Yu, Dahee
    Park, Eun Jung
    CANCER RESEARCH, 2023, 83 (07)
  • [45] Role of TIM-3/Galectin-9 pathway in lung cancer
    Ohue, Yoshihiro
    Kurose, Koji
    Nishio, Yumi
    Isobe, Midori
    Oka, Mikio
    Nakayama, Eiichi
    CANCER IMMUNOLOGY RESEARCH, 2016, 4 (11)
  • [46] Cell Surface Galectin-9 Expressing Th Cells Regulate Th17 and Foxp3+ Treg Development by Galectin-9 Secretion
    Oomizu, Souichi
    Arikawa, Tomohiro
    Niki, Toshiro
    Kadowaki, Takeshi
    Ueno, Masaki
    Nishi, Nozomu
    Yamauchi, Akira
    Hattori, Toshio
    Masaki, Tsutomu
    Hirashima, Mitsuomi
    PLOS ONE, 2012, 7 (11):
  • [47] The Dual Role of the NFATc2/galectin-9 Axis in Modulating Tumor-Initiating Cell Phenotypes and Immune Suppression in Lung Adenocarcinoma
    Xiao, Zhi-Jie
    Wang, Si-Qi
    Chen, Jun-Jiang
    Li, Yun
    Jiang, Yuchen
    Tin, Vicky Pui-Chi
    Liu, Jia
    Hu, Huiyi
    Wong, Maria Pik
    Pan, Yihang
    Yam, Judy Wai Ping
    ADVANCED SCIENCE, 2024, 11 (20)
  • [48] Galectin-9, A Novel Prognostic Factor in Small Cell Lung Cancer
    Chen, P.
    He, Y.
    Zhou, C.
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (03) : S498 - S498
  • [49] Galectin-8 and galectin-9 are novel substrates for thrombin
    Nishi, Nozomu
    Itoh, Aiko
    Shoji, Hiroki
    Miyanaka, Hiroshi
    Nakamura, Takanori
    GLYCOBIOLOGY, 2006, 16 (11) : 15C - 20C
  • [50] Galectin-9 Is a Suppressor of T and B Cells and Predicts the Immune Modulatory Potential of Mesenchymal Stromal Cell Preparations
    Ungerer, Christopher
    Quade-Lyssy, Patricia
    Radeke, Heinfried H.
    Henschler, Reinhard
    Koenigs, Christoph
    Koehl, Ulrike
    Seifried, Erhard
    Schuettrumpf, Joerg
    STEM CELLS AND DEVELOPMENT, 2014, 23 (07) : 755 - 766