galectin-9;
immune;
T cell;
strategies;
inhibitors;
NATURAL-KILLER-CELLS;
T-CELLS;
EOSINOPHIL CHEMOATTRACTANT;
PROGNOSTIC-SIGNIFICANCE;
DIVERSE ROLES;
SERUM-LEVELS;
ACTIVATION;
EXPRESSION;
TIM-3;
IMMUNOGLOBULIN;
D O I:
10.3389/fphar.2024.1462061
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Galectin-9 (gal-9) is a protein that belongs to the galectin family. Gal-9 is expressed in cells of the innate and adaptive immune system, including lymphocytes, dendritic cells, giant salivary cells, eosinophils and T cells, etc. In different immune cells, the role of gal-9 is different. Gal-9 can induce the proliferation and activation of immune cells, and also promote the apoptosis of immune cells. This effect of gal-9 affects the occurrence and development of a variety of immune-related diseases, such as the invasion of pathogenic microorganisms, immune escape of tumor cells, and inflammatory response. Thus, understanding the biological roles of gal-9 in innate and adaptive immunity may be essential for autoimmune diseases treatment and diagnosis to improve patient quality of life. In this review, we aim to summarize current research on the regulatory roles of gal-9 in human immune system and potential inducers and inhibitors of gal-9, which may provide new strategies for immune diseases therapies.
机构:
Univ Alberta, Fac Med & Dent, Dept Dent, Edmonton, AB T6G 2E1, Canada
Univ Alberta, Fac Med & Dent, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2E1, CanadaUniv Alberta, Fac Med & Dent, Dept Dent, Edmonton, AB T6G 2E1, Canada
Merani, Shahzma
Chen, Wenna
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机构:
Univ Alberta, Fac Med & Dent, Dept Dent, Edmonton, AB T6G 2E1, Canada
Univ Alberta, Fac Med & Dent, Dept Med Microbiol & Immunol, Edmonton, AB T6G 2E1, CanadaUniv Alberta, Fac Med & Dent, Dept Dent, Edmonton, AB T6G 2E1, Canada
机构:
Queen Mary Univ London, WHRI, Barts & London Sch Med & Dent, London, EnglandQueen Mary Univ London, WHRI, Barts & London Sch Med & Dent, London, England
Cooper, D.
Iqbal, A. J.
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机构:
Queen Mary Univ London, WHRI, Barts & London Sch Med & Dent, London, EnglandQueen Mary Univ London, WHRI, Barts & London Sch Med & Dent, London, England
Iqbal, A. J.
Niki, T.
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机构:
GalPharma Co Ltd, Div Res, Kagawa, JapanQueen Mary Univ London, WHRI, Barts & London Sch Med & Dent, London, England
Niki, T.
Hirashima, M.
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机构:
Kagawa Univ, Dept Immunol & Immunopathol, Kagawa, JapanQueen Mary Univ London, WHRI, Barts & London Sch Med & Dent, London, England
Hirashima, M.
Perretti, M.
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机构:
Queen Mary Univ London, WHRI, Barts & London Sch Med & Dent, London, EnglandQueen Mary Univ London, WHRI, Barts & London Sch Med & Dent, London, England