New Benzaldehyde Derivatives From the Soft Coral-Associated Epiphytic Fungus Aspergillus Sp. EGF 15-0-3

被引：0

作者：

Zhang, Ze-Kun ^{[1
]}

Li, Ze-Jun ^{[1
]}

Guo, Li-Shuang ^{[2
]}

Duan, Xue-Wei ^{[1
]}

Liu, Bing-Bing ^{[1
]}

An, Lin-Kun ^{[2
]}

He, Xi-Xin ^{[1
]}

Zhang, Cui-Xian ^{[1
]}

机构：

[1] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou, Peoples R China

[2] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2025年

基金：

中国国家自然科学基金;

关键词：

benzaldehyde derivatives; inhibitory effect; molecular docking; soft coral-associated epiphytic fungus; tyrosyl-DNA phosphodiesterase 1; tyrosyl-DNA phosphodiesterase 2; TOPOISOMERASES; INHIBITORS; TDP1;

D O I：

10.1002/cbdv.202500124

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new benzaldehyde derivatives, aspergitones A (1) and B (2), along with seven known analogues 3-9, were isolated from the soft coral-associated epiphytic fungus Aspergillus sp. EGF 15-0-3. Their structures were elucidated using 1D and 2D nuclear magnetic resonance (NMR) spectroscopy and high-resolution electrospray ionization mass spectrometry (HRESIMS), whereas the absolute configuration of 1 was determined through the experimental and computational ECD analysis. On the basis of the molecular docking and activity assays against the antitumor targets tyrosyl-DNA phosphodiesterases 1 and 2 (TDP1 and TDP2), compound 7 was found to be a potential dual inhibitor against TDP1 and TDP2, whereas 5 showed the strongest inhibition against TDP1.

引用

页数：6

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