A New Antibacterial Dihydroisocoumarin from the Marine Sponge-Associated Fungus Aspergillus sp.

被引：0
|
作者：
Sixiao Lin
Juan Li
Weizhong Chen
Jiaxin He
Yutong Shi
Haixiao Jin
Lijian Ding
机构：
[1] Ningbo University,Department of Marine Pharmacy, Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, College of Food and Pharmaceutical Sciences
来源：
Chemistry of Natural Compounds | 2023年 / 59卷
关键词：
sp.; dihydroisocoumarin; sponge-associated fungus; antibacterial activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A new dihydroisocoumarin, aspergimarin G (1), was isolated from the sponge-associated fungus Aspergillus sp. NBUF87. Its planar structure and absolute configuration were elucidated by comprehensive spectroscopic techniques, including HR-ESI-MS, 1D and 2D NMR, modified Mosher′s method as well as electronic circular dichroism. In the bioactivity assays, compound 1 showed moderate antibacterial activity toward Staphylococcus aureus and Salmonella enteritidis with MIC values ranging from 16 to 64 μg/mL. However, compound 1 was inactive in AChE inhibitory assay.
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页码：246 / 248
页数：2
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