Perianal leiomyosarcoma as a rare sequela of rectal cancer radiotherapy: a case report

被引:0
|
作者
Chen, Chaopeng [1 ]
Cai, Wenping [2 ]
Li, Yujiao [3 ]
Ren, Junqi [3 ]
Xu, Zhibin [4 ]
Pang, Lijuan [2 ]
Dai, Weiping [1 ]
机构
[1] Cent Hosp Guangdong Prov Nongken, Dept Pathol, Zhanjiang, Guangdong, Peoples R China
[2] Guangdong Med Univ, Cent Peoples Hosp Zhanjiang, Zhanjiang Cent Hosp, Dept Pathol, Zhanjiang, Guangdong, Peoples R China
[3] Guangdong Med Univ, Affiliated Hosp 2, Dept Pathol, Zhanjiang, Guangdong, Peoples R China
[4] Guangzhou Med Univ, Dept Organ Transplantat, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词
radiation-induced sarcoma (RIS); rectal adenocarcinoma; leiomyosarcoma; neoadjuvant chemoradiotherapy; pathological diagnosis;
D O I
10.3389/fonc.2024.1474536
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Radiation-induced sarcomas (RIS) are iatrogenic malignancies that arise following high-dose radiotherapy, posing a significant clinical challenge due to their poor prognosis and resistance to conventional treatments. The incidence of RIS is increasing with advancements in radiotherapy techniques. This report presents a case of a 71-year-old male diagnosed with stage III rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and curative surgery. Three years postoperatively, he developed a low-grade radiation-induced leiomyosarcoma in the perianal region. Histopathological examination confirmed a spindle cell neoplasm with notable immunohistochemical markers. RIS often presents as aggressive high-grade tumors resistant to radiotherapy and chemotherapy, necessitating surgical resection as the primary treatment. This case underscores the importance of long-term surveillance post-radiotherapy and highlights the need for innovative therapeutic strategies, including immunotherapy. Despite being rare, RIS poses a significant risk following cancer treatment, making early detection through vigilant monitoring and advancements in therapeutic approaches crucial for improving patient outcomes.
引用
收藏
页数:8
相关论文
共 50 条
  • [41] Primary intratesticular pleomorphic leiomyosarcoma: A rare case report
    Damle, Rajshri Pisaram
    Suryawanshi, Kishor H.
    Dravid, Nandkumar V.
    Newadkar, Dhananjay V.
    INDIAN JOURNAL OF PATHOLOGY AND MICROBIOLOGY, 2013, 56 (04) : 425 - 427
  • [42] A RARE COMPLICATION OF RECTAL CANCER: GANGRENOUS COLITIS- A CASE REPORT
    Chen, Zhi-Chao
    Wang, Jie-Fang
    Lin, Yong-Hua
    ACTA MEDICA MEDITERRANEA, 2022, 38 (03): : 1535 - 1537
  • [43] Leiomyosarcoma of Nose a Very Rare Tumor Case Report: Unusual Case Leiomyosarcoma Inferior Turbinate
    Thakkar, Himanshu
    INDIAN JOURNAL OF OTOLARYNGOLOGY AND HEAD & NECK SURGERY, 2021, 73 (02) : 137 - 139
  • [44] Rectal metastasis originating from breast cancer: A rare case report
    Hoang, Dung Anh
    Nguyen, Anh Quang
    Nguyen, Khuyen Thi
    Pham, Manh Duy
    ANNALS OF MEDICINE AND SURGERY, 2022, 78
  • [45] Rectal leiomyosarcoma, late complication of pelvic radiotherapy
    Oruc, Mehmet Tahir
    Mayir, Burhan
    Bilecik, Tuna
    Sakar, Alkan
    Erinekci, Ali Riza
    INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2015, 30 (04) : 571 - 572
  • [46] Exploring a Rare Malignant Lung Cancer - Primary Pulmonary Leiomyosarcoma: An Intriguing Case Report
    Villa, N. E.
    Munoz, C.
    Oliva, M.
    Shah, D. M.
    Pathakamudi, P.
    Torracchi, M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2024, 209
  • [47] Can pelvic radiotherapy induce a leiomyosarcoma of the prostate? (A case report)
    Bkiri, Saad
    Tlemsani, Zakaria
    Khdach, Youness
    Bennani, Karim
    Abbad, Faycal
    Ghadouane, Mohammed
    PAN AFRICAN MEDICAL JOURNAL, 2022, 43
  • [48] LEIOMYOSARCOMA OF THE BASE OF THE TONGUE TREATED WITH RADIOTHERAPY - A CASE-REPORT
    AYDIN, H
    DREYER, T
    ORAL ONCOLOGY-EUROPEAN JOURNAL OF CANCER PART B, 1994, 30B (05): : 351 - 355
  • [49] A rare case of a leiomyosarcoma
    Thomas, K.
    Rambocas, N.
    BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 2014, 121 : 3 - 3
  • [50] Perianal Paget's disease associated with rectal carcinoma: A case report
    Kubota, K
    Akasu, T
    Nakanishi, Y
    Sugihara, K
    Fujita, S
    Moriya, Y
    JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 1998, 28 (05) : 347 - 350