Perianal leiomyosarcoma as a rare sequela of rectal cancer radiotherapy: a case report

被引:0
|
作者
Chen, Chaopeng [1 ]
Cai, Wenping [2 ]
Li, Yujiao [3 ]
Ren, Junqi [3 ]
Xu, Zhibin [4 ]
Pang, Lijuan [2 ]
Dai, Weiping [1 ]
机构
[1] Cent Hosp Guangdong Prov Nongken, Dept Pathol, Zhanjiang, Guangdong, Peoples R China
[2] Guangdong Med Univ, Cent Peoples Hosp Zhanjiang, Zhanjiang Cent Hosp, Dept Pathol, Zhanjiang, Guangdong, Peoples R China
[3] Guangdong Med Univ, Affiliated Hosp 2, Dept Pathol, Zhanjiang, Guangdong, Peoples R China
[4] Guangzhou Med Univ, Dept Organ Transplantat, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词
radiation-induced sarcoma (RIS); rectal adenocarcinoma; leiomyosarcoma; neoadjuvant chemoradiotherapy; pathological diagnosis;
D O I
10.3389/fonc.2024.1474536
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Radiation-induced sarcomas (RIS) are iatrogenic malignancies that arise following high-dose radiotherapy, posing a significant clinical challenge due to their poor prognosis and resistance to conventional treatments. The incidence of RIS is increasing with advancements in radiotherapy techniques. This report presents a case of a 71-year-old male diagnosed with stage III rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and curative surgery. Three years postoperatively, he developed a low-grade radiation-induced leiomyosarcoma in the perianal region. Histopathological examination confirmed a spindle cell neoplasm with notable immunohistochemical markers. RIS often presents as aggressive high-grade tumors resistant to radiotherapy and chemotherapy, necessitating surgical resection as the primary treatment. This case underscores the importance of long-term surveillance post-radiotherapy and highlights the need for innovative therapeutic strategies, including immunotherapy. Despite being rare, RIS poses a significant risk following cancer treatment, making early detection through vigilant monitoring and advancements in therapeutic approaches crucial for improving patient outcomes.
引用
收藏
页数:8
相关论文
共 50 条
  • [21] Rectal prolapse following short-course radiotherapy for rectal cancer: report of a case
    Nocera, Fabio
    von Fluee, Markus
    Steinemann, Daniel C.
    JOURNAL OF SURGICAL CASE REPORTS, 2020, (12):
  • [22] Radiotherapy for perianal Paget's disease: a case report
    Velenik, Vaneja
    Segedin, Barbara
    Anderluh, Franc
    Oblak, Irena
    Strojan, Primoz
    TUMORI JOURNAL, 2008, 94 (05): : 750 - 753
  • [23] LEIOMYOSARCOMA OF COLON - REPORT OF A CASE POSSIBLY INDUCED BY RADIOTHERAPY
    LIBESKIND, M
    LUGAGNE, F
    MALBRAN, J
    TROUILLARD, J
    GUYETROUSSET, P
    ARCHIVES FRANCAISES DES MALADIES DE L APPAREIL DIGESTIF, 1976, 65 (03): : 227 - 233
  • [24] Radiotherapy treatment of large esophageal leiomyosarcoma: A case report
    Ma, Shuangshuang
    Bu, Wenzhe
    Wang, Lijun
    Li, Jinpeng
    Shi, Congcong
    Song, Jinlong
    Chen, Hua
    ONCOLOGY LETTERS, 2015, 9 (05) : 2422 - 2424
  • [25] Talar Extrusion, A Very Rare Sequela of Trauma: A Case Report
    Ortiz-Cruz, Joaquin R.
    Ojeda Boscana, Ivonne L.
    AMERICAN JOURNAL OF CASE REPORTS, 2019, 20 : 575 - 579
  • [26] Postoperative radiotherapy-induced leiomyosarcoma in breast cancer: a case report and literature review
    Liu, Yong
    Wang, Jiaming
    Su, Rong
    Tang, Yi
    Liao, Xiaoli
    BREAST CANCER, 2020, 27 (04) : 780 - 784
  • [27] Postoperative radiotherapy-induced leiomyosarcoma in breast cancer: a case report and literature review
    Yong Liu
    Jiaming Wang
    Rong Su
    Yi Tang
    Xiaoli Liao
    Breast Cancer, 2020, 27 : 780 - 784
  • [28] Pedunculated Perianal Mass in a Neonate: A Rare Case Report
    Aihole, Jayalaxmi Shripati
    AMERICAN JOURNAL OF DERMATOPATHOLOGY, 2020, 42 (08) : 601 - 603
  • [29] Axillary and perianal leiomyosarcoma: report of two cases
    Mesina, C.
    Vasile, I.
    Vilcea, I. D.
    Vere, C. C.
    Georgescu, Claudia Valentina
    Ghilusi, Mirela
    Pasalega, M.
    Parvanescu, H.
    Calota, F.
    Mogoanta, S. S.
    ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY, 2010, 51 (02): : 379 - 385
  • [30] A rare case of giant leiomyosarcoma in a filarial scrotum: a case report
    Talikoti, Majid Ahmed
    Deo, S. V. S.
    Shukla, Nootan K.
    Kallianpur, Ashwin A.
    Gupta, Mamraj
    WORLD JOURNAL OF SURGICAL ONCOLOGY, 2011, 9