Perianal leiomyosarcoma as a rare sequela of rectal cancer radiotherapy: a case report

被引:0
|
作者
Chen, Chaopeng [1 ]
Cai, Wenping [2 ]
Li, Yujiao [3 ]
Ren, Junqi [3 ]
Xu, Zhibin [4 ]
Pang, Lijuan [2 ]
Dai, Weiping [1 ]
机构
[1] Cent Hosp Guangdong Prov Nongken, Dept Pathol, Zhanjiang, Guangdong, Peoples R China
[2] Guangdong Med Univ, Cent Peoples Hosp Zhanjiang, Zhanjiang Cent Hosp, Dept Pathol, Zhanjiang, Guangdong, Peoples R China
[3] Guangdong Med Univ, Affiliated Hosp 2, Dept Pathol, Zhanjiang, Guangdong, Peoples R China
[4] Guangzhou Med Univ, Dept Organ Transplantat, Affiliated Hosp 2, Guangzhou, Guangdong, Peoples R China
来源
FRONTIERS IN ONCOLOGY | 2024年 / 14卷
关键词
radiation-induced sarcoma (RIS); rectal adenocarcinoma; leiomyosarcoma; neoadjuvant chemoradiotherapy; pathological diagnosis;
D O I
10.3389/fonc.2024.1474536
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Radiation-induced sarcomas (RIS) are iatrogenic malignancies that arise following high-dose radiotherapy, posing a significant clinical challenge due to their poor prognosis and resistance to conventional treatments. The incidence of RIS is increasing with advancements in radiotherapy techniques. This report presents a case of a 71-year-old male diagnosed with stage III rectal adenocarcinoma treated with neoadjuvant chemoradiotherapy and curative surgery. Three years postoperatively, he developed a low-grade radiation-induced leiomyosarcoma in the perianal region. Histopathological examination confirmed a spindle cell neoplasm with notable immunohistochemical markers. RIS often presents as aggressive high-grade tumors resistant to radiotherapy and chemotherapy, necessitating surgical resection as the primary treatment. This case underscores the importance of long-term surveillance post-radiotherapy and highlights the need for innovative therapeutic strategies, including immunotherapy. Despite being rare, RIS poses a significant risk following cancer treatment, making early detection through vigilant monitoring and advancements in therapeutic approaches crucial for improving patient outcomes.
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页数:8
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