RNA vaccines: The dawn of a new age for tuberculosis?

被引：0

作者：

Li, Junli ^{[1
,2
,3
,4
]}

Liu, Dong ^{[5
,6
]}

Li, Xiaochi ^{[1
,2
,3
,4
]}

Wei, Jiazheng ^{[7
]}

Du, Weixin ^{[1
,2
,3
,4
]}

Zhao, Aihua ^{[1
,2
,3
,4
]}

Xu, Miao ^{[1
,2
,3
,4
]}

机构：

[1] Natl Inst Food & Drug Control, Inst Biol Prod Control, Div TB Vaccine & Allergen, 31 Huatuo Rd,China Biomed Pk CBP, Beijing 102269, Peoples R China

[2] Natl Inst Food & Drug Control, State Key Lab Drug Regulatory Sci, Beijing, Peoples R China

[3] Natl Med Prod Adm NMPA, Key Lab Qual Res & Evaluat Biol Prod, Beijing, Peoples R China

[4] Natl Hlth Commiss NHC, Key Lab Res Qual & Standardizat Biotech Prod, Beijing, Peoples R China

[5] Guangzhou Med Univ, Grad Sch, Guangzhou, Peoples R China

[6] Guangzhou Lab, Guangzhou, Peoples R China

[7] Shenyang Pharmaceut Univ, Coll Life Sci & Biopharmaceut, Shenyang, Peoples R China

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2025年 / 21卷 / 01期

基金：

北京市自然科学基金;

关键词：

Tuberculosis; mRNA vaccines; Mycobacterium tuberculosis; immunological mechanisms; manufacture and quality control; MYCOBACTERIUM-TUBERCULOSIS; IN-VIVO; SOUTH-AFRICA; PURIFICATION; TRANSLATION; GENE; IMMUNOGENICITY; INITIATION; INDUCTION; STABILITY;

D O I：

10.1080/21645515.2025.2469333

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Since 2019, there has been a growing focus on mRNA vaccines for infectious disease prevention, particularly following the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). mRNA vaccines offer advantages such as rapid production and the ability to induce robust cellular and antibody responses, which are essential for combating infections that require cell-mediated immunity, including Tuberculosis (TB). This review explores recent progress in TB mRNA vaccines and addresses several key areas: (1) the urgent need for new TB vaccines; (2) current advancements in TB vaccine development, and the advantages and challenges of mRNA technology; (3) the design and characteristics of TB mRNA vaccines; (4) the immunological mechanisms of TB mRNA vaccines; (5) manufacturing processes for TB mRNA vaccines; and (6) safety and regulatory considerations. This interdisciplinary review aims to provide insights for researchers working to address critical questions in TB mRNA vaccine development.

引用

页数：17

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