RNA vaccines: The dawn of a new age for tuberculosis?

被引：0
|
作者：
Li, Junli [1 ,2 ,3 ,4 ]
Liu, Dong [5 ,6 ]
Li, Xiaochi [1 ,2 ,3 ,4 ]
Wei, Jiazheng [7 ]
Du, Weixin [1 ,2 ,3 ,4 ]
Zhao, Aihua [1 ,2 ,3 ,4 ]
Xu, Miao [1 ,2 ,3 ,4 ]
机构：
[1] Natl Inst Food & Drug Control, Inst Biol Prod Control, Div TB Vaccine & Allergen, 31 Huatuo Rd,China Biomed Pk CBP, Beijing 102269, Peoples R China
[2] Natl Inst Food & Drug Control, State Key Lab Drug Regulatory Sci, Beijing, Peoples R China
[3] Natl Med Prod Adm NMPA, Key Lab Qual Res & Evaluat Biol Prod, Beijing, Peoples R China
[4] Natl Hlth Commiss NHC, Key Lab Res Qual & Standardizat Biotech Prod, Beijing, Peoples R China
[5] Guangzhou Med Univ, Grad Sch, Guangzhou, Peoples R China
[6] Guangzhou Lab, Guangzhou, Peoples R China
[7] Shenyang Pharmaceut Univ, Coll Life Sci & Biopharmaceut, Shenyang, Peoples R China
来源：
HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2025年 / 21卷 / 01期
基金：
北京市自然科学基金;
关键词：
Tuberculosis; mRNA vaccines; Mycobacterium tuberculosis; immunological mechanisms; manufacture and quality control; MYCOBACTERIUM-TUBERCULOSIS; IN-VIVO; SOUTH-AFRICA; PURIFICATION; TRANSLATION; GENE; IMMUNOGENICITY; INITIATION; INDUCTION; STABILITY;
D O I：
10.1080/21645515.2025.2469333
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Since 2019, there has been a growing focus on mRNA vaccines for infectious disease prevention, particularly following the emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). mRNA vaccines offer advantages such as rapid production and the ability to induce robust cellular and antibody responses, which are essential for combating infections that require cell-mediated immunity, including Tuberculosis (TB). This review explores recent progress in TB mRNA vaccines and addresses several key areas: (1) the urgent need for new TB vaccines; (2) current advancements in TB vaccine development, and the advantages and challenges of mRNA technology; (3) the design and characteristics of TB mRNA vaccines; (4) the immunological mechanisms of TB mRNA vaccines; (5) manufacturing processes for TB mRNA vaccines; and (6) safety and regulatory considerations. This interdisciplinary review aims to provide insights for researchers working to address critical questions in TB mRNA vaccine development.
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页数：17
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