anti-Selective Carboacylation of Alkynes via Photoredox/Nickel Dual Catalysis

被引：0
|
作者：
Pan, Xian-Hua [1 ]
Shi, Chang-Xin [1 ]
Hou, Ya-Ping [1 ]
Wang, Li-Fang [1 ]
Niu, Rui-Qi [1 ]
Guo, Lei [1 ]
机构：
[1] Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 44期
基金：
中国国家自然科学基金;
关键词：
RAUHUT-CURRIER REACTIONS; ALKENES; KETONES;
D O I：
10.1021/acs.orglett.4c03439
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Here, we report an intermolecular carboacylation of terminal alkynes with tertiary and secondary alkyltrifluoroborates as well as acyl chlorides via photoredox/nickel dual catalysis, affording a varity of stereodefined trisubstituted enones in good to excellent yields and E stereoselectivity, through a radical relay process. This redox-neutral protocol exhibits excellent functional group tolerance, exclusive regio- and stereoselectivity, and broad compatibility with various acyl chlorides and alkyltrifluoroborates.
引用
收藏
页码：9498 / 9502
页数：5
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