Intermolecular Regioselective Alkylarylation of Vinylarenes via Photoredox/Nickel Dual Catalysis

被引：1
|
作者：
Pan, Xian-Hua [1 ]
Hou, Ya-Ping [1 ]
Shi, Chang-Xin [1 ]
Wang, Ya-Ping [2 ]
Niu, Rui-Qi [1 ]
Guo, Lei [1 ]
机构：
[1] Shanghai Inst Technol, Sch Perfume & Aroma Technol, Shanghai 201418, Peoples R China
[2] Shanghai BIOS Technol Co Ltd, Shanghai 201408, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 35期
基金：
中国国家自然科学基金;
关键词：
ASYMMETRIC HYDROGENATION; CROSS-COUPLINGS; ARYLATION; ALKENES; DIARYLALKANES;
D O I：
10.1021/acs.orglett.4c02205
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel photoredox/nickel dual catalytic intermolecular alkylarylation of vinylarenes with tertiary and secondary alkyltrifluoroborates and aryl bromides is described, which affords 1,1-diarylalkane frameworks that are found in various natural products as well as functionalized molecules in good to excellent yield and regioselectivity through a radical relay process. Notably, this redox-neutral reaction could proceed efficiently with good tolerance of various substrates, including a great diversity of commercially available (hetero)aryl bromides, alkyltrifluoroborates, and vinylarenes.
引用
收藏
页码：7291 / 7296
页数：6
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