Bionic synapses for real-time epileptic seizure control

被引：0
|
作者：
Liu, Chen [1 ,2 ]
Jiang, Yuting [3 ]
Mu, Xingda [5 ]
Chang, Xuling [4 ,5 ]
Zhang, Ye [4 ,5 ,6 ]
He, Xiaoxiao [3 ]
Zhu, Xiaojuan [3 ]
Sun, Wenbo [1 ]
Lu, Lehui [1 ,2 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Electroanalyt Chem, Changchun 130022, Peoples R China
[2] Univ Sci & Technol China, Hefei 230026, Peoples R China
[3] Northeast Normal Univ, Sch Life Sci, Engn Lab Brain Cognit & Brain Inspired Intelligenc, Changchun 130024, Peoples R China
[4] Chinese Acad Sci, Changchun Inst Opt Fine Mech & Phys, Changchun 130033, Peoples R China
[5] Changchun Spirits AI Technol Co Ltd, Changchun 130033, Peoples R China
[6] Univ Chinese Acad Sci, Beijing 100039, Peoples R China
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2025年 / 429卷
基金：
中国国家自然科学基金;
关键词：
Bionic materials; Epileptic seizure control; Brain-machine interfaces; Biotechnology; Ionic conductors; Electrophysiological signals; SKIN; ELECTRODES; NEURONS;
D O I：
10.1016/j.snb.2025.137304
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Real-time optogenetic devices that can intelligently react to abnormal changes in the electrophysiological signals of epilepsy patients are crucial for timely seizure control. Inspired by electrical synapses, we report a bionic synapse built with entirely transparent ionic conductors. This system forms a soft, flexible network that allows free ionic movement, mimicking natural synaptic behavior. The bionic conductive technology is demonstrated in the application for brain signal recording-an emotion detection sensor. We also explore the potential of this technology for use in neural activity detections during optogenetic stimulation and emphasize its advantages in compromising optical recording. Furthermore, we have implemented this device for epileptic seizure control by real-time optogenetic modulation, which offers good potential for brain-machine interfaces in the monitoring and treatment of diseases. Our work highlights the advantages of transparent ionic conductors in combining electrophysiological recording and neural modulation, advancing both neurotechnology and bioelectronics.
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页数：12
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