The evolutionary history of metastatic pancreatic neuroendocrine tumors reveals a therapy driven route to high-grade transformation

被引：0
|
作者：
Backman, S. [1 ]
Botling, J. [2 ,3 ]
Nord, H. [4 ]
Ghosal, S. [5 ]
Stalberg, P. [1 ]
Juhlin, C. C. [6 ]
Hellman, P. [1 ]
Skogseid, B. [7 ]
Pacak, K. [5 ]
Mollazadegan, K. [7 ]
Akerstrom, T. [1 ]
Crona, J. [7 ]
机构：
[1] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden
[2] Uppsala Univ, Uppsala, Sweden
[3] Univ Gothenburg, Gothenburg, Sweden
[4] Uppsala Univ, Dept Immunol Genet & Pathol, Uppsala, Sweden
[5] NIH, Sect Med Neuroendocrinol, Bethesda, MD USA
[6] Karolinska Inst, Dept Oncol Pathol, Stockholm, Sweden
[7] Uppsala Univ, Dept Med Sci, Uppsala, Sweden
来源：
JOURNAL OF NEUROENDOCRINOLOGY | 2024年 / 36卷
关键词：
pancreatic neuroendocrine tumor; tumor evolution; alkylating chemotherapy; treatment resistance;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A03
引用
收藏
页码：20 / 20
页数：1
相关论文
共 50 条
  • [21] Pancreatic adenocarcinoma and pancreatic high-grade neuroendocrine carcinoma: two sides of the moon
    Anna La Salvia
    Irene Persano
    Elena Parlagreco
    Alessandro Audisio
    Massimiliano Cani
    Maria Pia Brizzi
    Medical Oncology, 39
  • [22] Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors
    Julie George
    Vonn Walter
    Martin Peifer
    Ludmil B. Alexandrov
    Danila Seidel
    Frauke Leenders
    Lukas Maas
    Christian Müller
    Ilona Dahmen
    Tiffany M. Delhomme
    Maude Ardin
    Noemie Leblay
    Graham Byrnes
    Ruping Sun
    Aurélien De Reynies
    Anne McLeer-Florin
    Graziella Bosco
    Florian Malchers
    Roopika Menon
    Janine Altmüller
    Christian Becker
    Peter Nürnberg
    Viktor Achter
    Ulrich Lang
    Peter M. Schneider
    Magdalena Bogus
    Matthew G. Soloway
    Matthew D. Wilkerson
    Yupeng Cun
    James D. McKay
    Denis Moro-Sibilot
    Christian G. Brambilla
    Sylvie Lantuejoul
    Nicolas Lemaitre
    Alex Soltermann
    Walter Weder
    Verena Tischler
    Odd Terje Brustugun
    Marius Lund-Iversen
    Åslaug Helland
    Steinar Solberg
    Sascha Ansén
    Gavin Wright
    Benjamin Solomon
    Luca Roz
    Ugo Pastorino
    Iver Petersen
    Joachim H. Clement
    Jörg Sänger
    Jürgen Wolf
    Nature Communications, 9
  • [23] Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors
    George, Julie
    Walter, Vonn
    Peifer, Martin
    Alexandrov, Ludmil B.
    Seidel, Danila
    Leenders, Frauke
    Maas, Lukas
    Mueller, Christian
    Dahmen, Ilona
    Delhomme, Tiffany M.
    Ardin, Maude
    Leblay, Noemie
    Byrnes, Graham
    Sun, Ruping
    De Reynies, Aurelien
    McLeer-Florin, Anne
    Bosco, Graziella
    Malchers, Florian
    Menon, Roopika
    Altmuller, Janine
    Becker, Christian
    Nurnberg, Peter
    Achter, Viktor
    Lang, Ulrich
    Schneider, Peter M.
    Bogus, Magdalena
    Soloway, Matthew G.
    Wilkerson, Matthew D.
    Cun, Yupeng
    McKay, James D.
    Moro-Sibilot, Denis
    Brambilla, Christian G.
    Lantuejoul, Sylvie
    Lemaitre, Nicolas
    Soltermann, Alex
    Weder, Walter
    Tischler, Verena
    Brustugun, Odd Terje
    Lund-Iversen, Marius
    Helland, Aslaug
    Solberg, Steinar
    Ansen, Sascha
    Wright, Gavin
    Solomon, Benjamin
    Roz, Luca
    Pastorino, Ugo
    Petersen, Iver
    Clement, Joachim H.
    Saenger, Jorg
    Wolf, Jurgen
    NATURE COMMUNICATIONS, 2018, 9
  • [24] High-grade transformation of pancreatic neuroendocrine tumor associated with TP53 mutations: A diagnostic pitfall mimicking neuroendocrine carcinoma
    Tanaka, Mariko
    Shinozaki-Ushiku, Aya
    Kunita, Akiko
    Yasunaga, Yoichi
    Akamatsu, Nobuhisa
    Hasegawa, Kiyoshi
    Ushiku, Tetsuo
    PATHOLOGY INTERNATIONAL, 2022, 72 (08) : 411 - 418
  • [25] Evolutionary Trajectories of Primary and Metastatic Pancreatic Neuroendocrine Tumors Based on Genomic Variations
    Xu, Midie
    Yan, Jiuliang
    Hu, Beiyuan
    Wu, Chuntao
    Gu, Haitao
    Qi, Zihao
    Chen, Tao
    Yang, Wenting
    Zheng, Yan
    Dong, Hanguang
    Sheng, Weiqi
    Long, Jiang
    GENES, 2022, 13 (09)
  • [26] Pancreatic High-Grade Neuroendocrine Neoplasms in the Korean Population: A Multicenter Study
    Kim, Haeryoung
    An, Soyeon
    Lee, Kyoungbun
    Ahn, Sangjeong
    Park, Youn
    Kim, Jo-Heon
    Kang, Dong-Wook
    Kim, Min-Ju
    Chang, Mee Soo
    Jung, Eun Sun
    Kim, Joon Mee
    Choi, Yoon Jung
    Jin, So-Young
    Chang, Hee Kyung
    Cho, Mee-Yon
    Kang, Yun Kyung
    Kang, Myunghee
    Ahn, Soomin
    Kim, Youn Wha
    Hong, Seung-Mo
    CANCER RESEARCH AND TREATMENT, 2020, 52 (01): : 263 - 276
  • [27] Clinicopathologic feature and treatment progress of high-grade ovarian neuroendocrine tumors
    He, Qionghua
    Wang, Chenyan
    Huang, Da
    Shen, Jiayu
    Liu, Rui
    Guan, Yutao
    Zhou, Jianwei
    MEDICAL ONCOLOGY, 2024, 42 (01)
  • [28] Treatment Outcomes of Well-Differentiated High-Grade Neuroendocrine Tumors
    Liu, A.
    Ueberroth, B.
    McGarrah, P.
    Petty, S. A. Buckner
    Kendi, A.
    Starr, J.
    Hobday, T.
    Halfdanarson, T. R.
    Sonbol, M. B.
    PANCREAS, 2021, 50 (03) : 448 - 448
  • [29] Treatment Outcomes of Well-Differentiated High-Grade Neuroendocrine Tumors
    Liu, Alex J.
    Ueberroth, Benjamin E.
    McGarrah, Patrick W.
    Buckner Petty, Skye A.
    Kendi, Ayse Tuba
    Starr, Jason
    Hobday, Timothy J.
    Halfdanarson, Thorvardur R.
    Sonbol, Mohamad Bassam
    ONCOLOGIST, 2021, 26 (05): : 383 - 388
  • [30] Characterization of high-grade neuroendocrine tumors of the lung in relation to menin mutations
    Haruki, N
    Yatabe, Y
    Travis, WD
    Nomoto, S
    Osada, H
    Nakamura, S
    Nakao, A
    Fujii, Y
    Takahashi, T
    JAPANESE JOURNAL OF CANCER RESEARCH, 2000, 91 (03): : 317 - 323
12345