Hidradenitis suppurativa pathogenesis: Extrinsic factors

被引：1

作者：

Nielsen, Valdemar Wendelboe ^{[2
]}

Thomsen, Simon Francis ^{[1
,3
]}

Naik, Haley B. ^{[4
]}

机构：

[1] Copenhagen Univ Hosp Bispebjerg & Frederiksberg, Dept Dermatovenereol, Copenhagen, Denmark

[2] Copenhagen Univ Hosp Bispebjerg & Frederiksberg, Wound Healing Ctr, Copenhagen, Denmark

[3] Univ Copenhagen, Dept Biomed Sci, Copenhagen, Denmark

[4] Univ Calif San Francisco, Dept Dermatol, 1701 Divisadero St,Suite 4-20, San Francisco, CA 94115 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2024年 / 91卷 / 06期

关键词：

extrinsic; hidradenitis suppurativa; mechanical stress; pathogenesis; BACTERIAL BIOFILM; MECHANICAL-STRESS; SKIN MICROBIOME; DIET; PREVALENCE; SMOKING; LESIONS; WEIGHT;

D O I：

10.1016/j.jaad.2024.07.1524

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

While genetic predisposition and immune dysregulation are recognized as key contributors to the development of hidradenitis suppurativa, accumulating research points to the influence of extrinsic factors in the pathogenesis of this condition. This review explores the roles of mechanical stress, altered skin and gut microbiome, tobacco smoking, diet, and paradoxical drug reactions as drivers of hidradenitis suppurativa onset and progression. A holistic management approach addressing these factors may be encouraged to improve disease outcomes. Further research is needed to fully determine the causal role of these extrinsic factors and their impact on treatment strategies. ( J Am Acad Dermatol 2024;91:S17-21.)

引用

页码：S17 / S21

页数：5

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