(2R,6R)-HYDROXYNORKETAMINE TARGETING THE BASOLATERAL AMYGDALA REGULATES FEAR MEMORY

被引：0
|
作者：
Xu, Yuanyuan [1 ]
Li, Zhenlong [2 ]
Lee, Chau-Shoun [3 ,4 ]
Peng, Hsien-Yu [3 ]
Lin, Tzer-Bin [5 ,6 ,7 ]
Hsieh, Ming-Chun [3 ]
Lai, Cheng-Yuan [8 ]
Chou, Dylan [3 ,9 ]
机构：
[1] Zunyi Med Univ, Dept Pharmacol, Zhuhai Campus, Zhuhai, Peoples R China
[2] Zunyi Med Univ, Sch Basic Med Sci, Zhuhai Campus, Zhuhai, Peoples R China
[3] MacKay Med Coll, Dept Med, Taipei, Taiwan
[4] Mackay Mem Hosp, Dept Psychiat, Taipei, Taiwan
[5] China Med Univ, Coll Med, Inst New Drug Dev, Taichung, Taiwan
[6] Taipei Med Univ, Wan Fang Hosp, Cell Physiol & Mol Image Res Ctr, Taipei, Taiwan
[7] Taipei Med Univ, Coll Med, Sch Med, Dept Physiol, Taipei, Taiwan
[8] MacKay Med Coll, Inst Biomed Sci, Taipei, Taiwan
[9] Zunyi Med Univ, Dept Physiol, Zhuhai Campus, Zhuhai, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2025年 / 28卷
关键词：
(2R; 6R)-hydroxynorketamine; long-term potentiation; basolateral amygdala; synaptic transmission; fear memory extinction;
D O I：
10.1093/ijnp/pyae059.383
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
pyae059.38
引用
收藏
页码：i218 / i218
页数：1
相关论文
共 50 条
  • [31] Effectiveness of Ketamine and (2R,6R)-Hydroxynorketamine to Reverse Anhedonia Subtypes Induced by Stress in Mice
    Georgiou, Polymnia
    Rajasekar, Thatchana
    Liu, Chao
    Zanos, Panos
    Gould, Todd
    NEUROPSYCHOPHARMACOLOGY, 2019, 44 (SUPPL 1) : 136 - 136
  • [32] Now is the time for (2R,6R)-hydroxynorketamine to be viewed independently from its parent drug
    Chaki, Shigeyuki
    Yamaguchi, Jun-ichi
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2018, 175 : 24 - 26
  • [33] Mediation of the behavioral effects of ketamine and (2R,6R)-hydroxynorketamine in mice by kappa opioid receptors
    Wulf, Hildegard A.
    Browne, Caroline A.
    Zarate, Carlos A.
    Lucki, Irwin
    PSYCHOPHARMACOLOGY, 2022, 239 (07) : 2309 - 2316
  • [34] Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine
    Shirayama, Yukihiko
    Hashimoto, Kenji
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2018, 21 (01): : 84 - 88
  • [35] Interactions of (2S,6S;2R,6R)-Hydroxynorketamine, a Secondary Metabolite of (R,S)-Ketamine, with Morphine
    Lilius, Tuomas O.
    Viisanen, Hanna
    Jokinen, Viljami
    Niemi, Mikko
    Kalso, Eija A.
    Rauhala, Pekka V.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2018, 122 (05) : 481 - 488
  • [36] Synaptic Mechanisms by Which (2R,6R)-Hydroxynorketamine Promotes Hippocampal-Dependent Plasticity and Behavior
    Riggs, Lace
    Mou, Ta-Chung
    Aronson, Sage
    Aracava, Yasco
    An, Xiaoxian
    Pereira, Edna
    Thompson, Scott
    Gould, Todd
    BIOLOGICAL PSYCHIATRY, 2022, 91 (09) : S244 - S245
  • [37] (2R,6R)-hydroxynorketamine rapidly potentiates optically-evoked Schaffer collateral synaptic activity
    Riggs, Lace M.
    Thompson, Scott M.
    Gould, Todd D.
    NEUROPHARMACOLOGY, 2022, 214
  • [38] Ketamine metabolite (2R,6R)-hydroxynorketamine enhances aggression via periaqueductal gray glutamatergic transmission
    Ye, Lichao
    Ko, Chih-Yuan
    Huang, Yuting
    Zheng, Chen
    Zheng, Yanfang
    Chou, Dylan
    NEUROPHARMACOLOGY, 2019, 157
  • [39] Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2,6)- and (5R)-Methyl-(2R,6R)-hydroxynorketamines
    Highland, Jaclyn N.
    Morris, Patrick J.
    Konrath, Kylie M.
    Riggs, Lace M.
    Hagen, Natalie R.
    Zanos, Panos
    Powels, Chris F.
    Moaddel, Ruin
    Thomas, Craig J.
    Wang, Amy Q.
    Gould, Todd D.
    ACS CHEMICAL NEUROSCIENCE, 2022, 13 (04): : 510 - 523
  • [40] Molecular evolution of a cytochrome P450 for the synthesis of potential antidepressant (2R,6R)-hydroxynorketamine
    Bokel, Ansgar
    Hutter, Michael C.
    Urlacher, Vlada B.
    CHEMICAL COMMUNICATIONS, 2021, 57 (04) : 520 - 523
12345