(2R,6R)-HYDROXYNORKETAMINE TARGETING THE BASOLATERAL AMYGDALA REGULATES FEAR MEMORY

被引:0
|
作者
Xu, Yuanyuan [1 ]
Li, Zhenlong [2 ]
Lee, Chau-Shoun [3 ,4 ]
Peng, Hsien-Yu [3 ]
Lin, Tzer-Bin [5 ,6 ,7 ]
Hsieh, Ming-Chun [3 ]
Lai, Cheng-Yuan [8 ]
Chou, Dylan [3 ,9 ]
机构
[1] Zunyi Med Univ, Dept Pharmacol, Zhuhai Campus, Zhuhai, Peoples R China
[2] Zunyi Med Univ, Sch Basic Med Sci, Zhuhai Campus, Zhuhai, Peoples R China
[3] MacKay Med Coll, Dept Med, Taipei, Taiwan
[4] Mackay Mem Hosp, Dept Psychiat, Taipei, Taiwan
[5] China Med Univ, Coll Med, Inst New Drug Dev, Taichung, Taiwan
[6] Taipei Med Univ, Wan Fang Hosp, Cell Physiol & Mol Image Res Ctr, Taipei, Taiwan
[7] Taipei Med Univ, Coll Med, Sch Med, Dept Physiol, Taipei, Taiwan
[8] MacKay Med Coll, Inst Biomed Sci, Taipei, Taiwan
[9] Zunyi Med Univ, Dept Physiol, Zhuhai Campus, Zhuhai, Peoples R China
关键词
(2R; 6R)-hydroxynorketamine; long-term potentiation; basolateral amygdala; synaptic transmission; fear memory extinction;
D O I
10.1093/ijnp/pyae059.383
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
pyae059.38
引用
收藏
页码:i218 / i218
页数:1
相关论文
共 50 条
  • [21] Ketamine increases vmPFC activity: Effects of (R)- and (S)-stereoisomers and (2R, 6R)-hydroxynorketamine metabolite
    Hare, Brendan D.
    Pothula, Santosh
    DiLeone, Ralph J.
    Duman, Ronald S.
    NEUROPHARMACOLOGY, 2020, 166
  • [22] Ketamine Increases vmPFC Activity: Effects of (R)- and (S)-Stereoisomers and (2R,6R) Hydroxynorketamine Metabolite
    Hare, Brendan
    Pothula, Santosh
    DiLeone, Ralph
    Duman, Ronald
    BIOLOGICAL PSYCHIATRY, 2020, 87 (09) : S191 - S191
  • [23] Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine
    Briana K. Chen
    Victor M. Luna
    Christina T. LaGamma
    Xiaoming Xu
    Shi-Xian Deng
    Raymond F. Suckow
    Thomas B. Cooper
    Abhishek Shah
    Rebecca A. Brachman
    Indira Mendez-David
    Denis J. David
    Alain M. Gardier
    Donald W. Landry
    Christine A. Denny
    Neuropsychopharmacology, 2020, 45 : 1545 - 1556
  • [24] Sex-specific neurobiological actions of prophylactic (R,S)-ketamine, (2R,6R)-hydroxynorketamine, and (2S,6S)-hydroxynorketamine
    Chen, Briana K.
    Luna, Victor M.
    LaGamma, Christina T.
    Xu, Xiaoming
    Deng, Shi-Xian
    Suckow, Raymond F.
    Cooper, Thomas B.
    Shah, Abhishek
    Brachman, Rebecca A.
    Mendez-David, Indira
    David, Denis J.
    Gardier, Alain M.
    Landry, Donald W.
    Denny, Christine A.
    NEUROPSYCHOPHARMACOLOGY, 2020, 45 (09) : 1545 - 1556
  • [25] Intranasal (2R, 6R)-hydroxynorketamine for acute pain: Behavioural and neurophysiological safety analysis in mice
    Goswami, Nidhi
    Aleem, Mohd
    Manda, Kailash
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023, 50 (02) : 169 - 177
  • [26] Ketamine metabolite (2R,6R)-hydroxynorketamine reverses behavioral despair produced by adolescent trauma
    Elmer, Greg, I
    Tapocik, Jenica D.
    Mayo, Cheryl L.
    Zanos, Panos
    Gould, Todd D.
    PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2020, 196
  • [27] Mediation of the behavioral effects of ketamine and (2R,6R)-hydroxynorketamine in mice by kappa opioid receptors
    Hildegard A. Wulf
    Caroline A. Browne
    Carlos A. Zarate
    Irwin Lucki
    Psychopharmacology, 2022, 239 : 2309 - 2316
  • [28] (2R,6R)-hydroxynorketamine (HNK) reverses mechanical hypersensitivity in a model of localized inflammatory pain
    Yost, Jonathan G.
    Browne, Caroline A.
    Lucki, Irwin
    NEUROPHARMACOLOGY, 2022, 221
  • [29] Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of (2R,6R)-hydroxynorketamine
    Highland, Jaclyn N.
    Morris, Patrick J.
    Zanos, Panos
    Lovett, Jacqueline
    Ghosh, Soumita
    Wang, Amy Q.
    Zarate, Carlos A., Jr.
    Thomas, Craig J.
    Moaddel, Ruin
    Gould, Todd D.
    JOURNAL OF PSYCHOPHARMACOLOGY, 2019, 33 (01) : 12 - 24
  • [30] (2R,6R)-hydroxynorketamine exerts mGlu2 receptor-dependent antidepressant actions
    Zanos, Panos
    Highland, Jaclyn N.
    Stewart, Brent W.
    Georgiou, Polymnia
    Jenne, Carleigh E.
    Lovett, Jacqueline
    Morris, Patrick J.
    Thomas, Craig J.
    Moaddel, Ruin
    Zarate, Carlos A., Jr.
    Gould, Todd D.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (13) : 6441 - 6450