(2R,6R)-HYDROXYNORKETAMINE TARGETING THE BASOLATERAL AMYGDALA REGULATES FEAR MEMORY

被引：0
|
作者：
Xu, Yuanyuan [1 ]
Li, Zhenlong [2 ]
Lee, Chau-Shoun [3 ,4 ]
Peng, Hsien-Yu [3 ]
Lin, Tzer-Bin [5 ,6 ,7 ]
Hsieh, Ming-Chun [3 ]
Lai, Cheng-Yuan [8 ]
Chou, Dylan [3 ,9 ]
机构：
[1] Zunyi Med Univ, Dept Pharmacol, Zhuhai Campus, Zhuhai, Peoples R China
[2] Zunyi Med Univ, Sch Basic Med Sci, Zhuhai Campus, Zhuhai, Peoples R China
[3] MacKay Med Coll, Dept Med, Taipei, Taiwan
[4] Mackay Mem Hosp, Dept Psychiat, Taipei, Taiwan
[5] China Med Univ, Coll Med, Inst New Drug Dev, Taichung, Taiwan
[6] Taipei Med Univ, Wan Fang Hosp, Cell Physiol & Mol Image Res Ctr, Taipei, Taiwan
[7] Taipei Med Univ, Coll Med, Sch Med, Dept Physiol, Taipei, Taiwan
[8] MacKay Med Coll, Inst Biomed Sci, Taipei, Taiwan
[9] Zunyi Med Univ, Dept Physiol, Zhuhai Campus, Zhuhai, Peoples R China
来源：
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | 2025年 / 28卷
关键词：
(2R; 6R)-hydroxynorketamine; long-term potentiation; basolateral amygdala; synaptic transmission; fear memory extinction;
D O I：
10.1093/ijnp/pyae059.383
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
pyae059.38
引用
收藏
页码：i218 / i218
页数：1
相关论文
共 50 条
  • [1] (2R,6R)-hydroxynorketamine targeting the basolateral amygdala regulates fear memory
    Xu, Yuanyuan
    Yu, Zhenfei
    Chen, Si
    Li, Zhenlong
    Long, Xiting
    Chen, Mengxu
    Lee, Chau-Shoun
    Peng, Hsien-Yu
    Lin, Tzer-Bin
    Hsieh, Ming-Chun
    Lai, Cheng -Yuan
    Chou, Dylan
    NEUROPHARMACOLOGY, 2023, 225
  • [2] A Concise Synthesis of (2R,6R)-Hydroxynorketamine
    Li, Jianfeng
    Zhou, Ankun
    Wang, Xiaoting
    Zhang, Wenping
    Zhou, Qixin
    Li, Ning
    JOURNAL OF ORGANIC CHEMISTRY, 2024, 89 (22): : 16909 - 16916
  • [3] Antinociceptive and Analgesic Effects of (2R,6R)-Hydroxynorketamine
    Yost, Jonathan G.
    Wulf, Hildegard A.
    Browne, Caroline A.
    Lucki, Irwin
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2022, 382 (03): : 256 - 265
  • [4] The effects of (2R,6R)-hydroxynorketamine on oxycodone withdrawal and reinstatement
    Drinkuth, Caryssa R.
    Lehane, Michael J.
    Sartor, Gregory C.
    DRUG AND ALCOHOL DEPENDENCE, 2023, 253
  • [5] (R,S)-ketamine and (2R,6R)-hydroxynorketamine differentially affect memory as a function of dosing frequency
    Riggs, Lace M.
    An, Xiaoxian
    Pereira, Edna F. R.
    Gould, Todd D.
    TRANSLATIONAL PSYCHIATRY, 2021, 11 (01)
  • [6] (R,S)-ketamine and (2R,6R)-hydroxynorketamine differentially affect memory as a function of dosing frequency
    Lace M. Riggs
    Xiaoxian An
    Edna F. R. Pereira
    Todd D. Gould
    Translational Psychiatry, 11
  • [7] (2R,6R)-Hydroxynorketamine is not essential for the antidepressant actions of (R)-ketamine in mice
    Yamaguchi, Jun-ichi
    Toki, Hidetoh
    Qu, Youge
    Yang, Chun
    Koike, Hiroyuki
    Hashimoto, Kenji
    Mizuno-Yasuhira, Akiko
    Chaki, Shigeyuki
    NEUROPSYCHOPHARMACOLOGY, 2018, 43 (09) : 1900 - 1907
  • [8] Ketamine Metabolite (2R,6R)-Hydroxynorketamine Interacts with μ and κ Opioid Receptors
    Joseph, Thomas T.
    Bu, Weiming
    Lin, Wenzhen
    Zoubak, Lioudmila
    Yeliseev, Alexei
    Liu, Renyu
    Eckenhoff, Roderic G.
    Brannigan, Grace
    ACS CHEMICAL NEUROSCIENCE, 2021, 12 (09): : 1487 - 1497
  • [9] Target Deconvolution Studies of (2R,6R)-Hydroxynorketamine: An Elusive Search
    Bonaventura, Jordi
    Gomez, Juan L.
    Lam, Sherry
    Soto, Marta Sanchez
    Morris, Patrick J.
    Zanos, Panos
    Moaddel, Ruin
    Gould, Todd D.
    Sibley, David R.
    Thomas, Craig J.
    Zarate, Carlos A., Jr.
    Michaelides, Mike
    NEUROPSYCHOPHARMACOLOGY, 2021, 46 (SUPPL 1) : 194 - 194
  • [10] Target deconvolution studies of (2R,6R)-hydroxynorketamine: an elusive search
    Jordi Bonaventura
    Juan L. Gomez
    Meghan L. Carlton
    Sherry Lam
    Marta Sanchez-Soto
    Patrick J. Morris
    Ruin Moaddel
    Hye Jin Kang
    Panos Zanos
    Todd D. Gould
    Craig J. Thomas
    David R. Sibley
    Carlos A. Zarate
    Michael Michaelides
    Molecular Psychiatry, 2022, 27 : 4144 - 4156
12345